IndraLab

Statements

PRKCA inhibits AKT. 10 / 22
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"Importantly, PKCalpha signaling was able to suppress AKT activity even in the face of further activation of the pathway."
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"Remarkably, knockdown of PKCalpha in cells with genetic hyperactivation of the PI3K and AKT pathway further enhanced the activity of AKT, highlighting the ability of PKCalpha deficiency to contribute to the strength of PI3K and AKT signaling in EC cells."
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"As discussed above, inhibition of AKT by PKCα in HeLa cells destabilized the de-ubiquitinase, USP8, leading to enhanced ubiquitination and degradation of EGFR ( xref )."
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"Given that Akt activation is PKCalpha dependent, we next examined whether the expression of a membrane targeted form of PKCalpha (myrPKCalpha) could rescue Akt activation in S4 -/- endothelial cells."
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"Remarkably, PKCalpha knockdown also upregulated basal AKT activity in HEC-6 and SNG-M cells, two PTEN mutant cell lines that naturally harbor coincident mutations in the catalytic (PIK3CA) or regulato[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This effect is consistent with the known inhibition of Akt by PKCα ( xref ), the only cPKC expressed in these cells ( xref )."
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"Future studies will explore the specific PP2A family members involved as well as the specific holoenzyme complex(es) responsible for mediating PKCα-induced inactivation of AKT."
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"Remarkably, PKCalpha knockdown also upregulated basal AKT activity in HEC-6 and SNG-M cells, two PTEN mutant cell lines that naturally harbor coincident mutations in the catalytic (PIK3CA) or regulatory (PIK3R1) subunits of PI3K, respectively (XREF_FIG, middle and right panels; also see XREF_FIG, compare lane 1 with lanes 3-6 in both panels)."
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"It is conceived that presence of obesity-induced DAG accumulation in the heart signified the development of cardiac insulin resistance through PKCα-dependent inhibition of Akt, p70s6k activation, and IRS-1 Ser332/336 phosphorylation (496)."
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"Together, these results indicate that PKCalpha inhibits PI3K and AKT signaling through a PHLPP independent, PP2A-family-dependent mechanism."
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Kinase-active PRKCA inhibits AKT. 1 / 1
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"Modified assertion"
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