A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

PRKCA activates RAF1. 8 / 17
2 | 3 6 2
reach
"PKCalpha promotes activation of Raf1 by direct phosphorylation [XREF_BIBR, XREF_BIBR]."
sparser
"PKCa activates raf-1 by direct phosporylation."
trips
"PKC alpha directly phosphorylates and activates Raf-1 both in vitro and in vivo."
trips
"Mutation of serine at this position or at residue 259 does not abrogate Raf-1 stimulation by a combination of Ras plus the src tyrosine kinase Lck, but severely impedes Raf-1 activation by PKC alpha."
signor
"Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation."
sparser
"Raf-1 is also activated independently of Ras by Bcl-2 and PKC-α."
sparser
"It is reported that PKC-alpha can directly phosphorylate or activate Raf-1 in NIH3 T3 cells."
signor
"Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation."
Kinase-active PRKCA activates RAF1. 1 / 1
1 |
bel
"which are involved in cytokine signaling.86 Other Rasindependent activators of Raf include interferon beta, protein kinase C (PKC) alpha, antiapoptotic proteins (eg, Bcl-2), scaffolding proteins (eg, ceramide-activated protein kinase), ultraviolet light, ionizing radiation, retinoids, erythropoietin, and dimerization between Raf isoforms86-94 (Fig 3)."
PRKCA activates RAF1. 1 / 1
1 |
bel
"PKC alpha directly phosphorylates and activates Raf-1 both in vitro and in vivo."