IndraLab

Statements


PRKCA activates RAF1. 10 / 26
2 | 3 9 8

"Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation."

sparser
"In patients treated with BRAF inhibitors, PKCα-dependent activation of RAF1 provides a means for reactivation of ERK signaling."

reach
"It has been proposed that the PKC-alpha isoform directly phosphorylates and activates the proto-oncogene Raf-1 to initiate signaling via the MAP kinase cascade [33] and that cell growth is dependent o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"PKCα activates RAF1, which in turn activates MEK1, and activates downstream transcriptional targets of MAPK through activation of JNK signaling."

sparser
"PKCa activates raf-1 by direct phosporylation."

trips
"PKC alpha directly phosphorylates and activates Raf-1 both in vitro and in vivo."

reach
"PKCa activates raf-1 by direct phosporylation."

reach
"Raf-1 is also activated independently of Ras by Bcl-2 and PKC-alpha."

trips
"Mutation of serine at this position or at residue 259 does not abrogate Raf-1 stimulation by a combination of Ras plus the src tyrosine kinase Lck, but severely impedes Raf-1 activation by PKC alpha."

sparser
"First, PKCα activates RAF1, which leads to activation of MAPK signaling independent of upstream activation of BRAF and NRAS."
PRKCA activates RAF1. 1 / 1
1 |

"PKC alpha directly phosphorylates and activates Raf-1 both in vitro and in vivo."
Kinase-active PRKCA activates RAF1. 1 / 1
1 |

"which are involved in cytokine signaling.86 Other Rasindependent activators of Raf include interferon beta, protein kinase C (PKC) alpha, antiapoptotic proteins (eg, Bcl-2), scaffolding proteins (eg, ceramide-activated protein kinase), ultraviolet light, ionizing radiation, retinoids, erythropoietin, and dimerization between Raf isoforms86-94 (Fig 3)."