A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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"PPARgamma agonists induce lipogenesis and adipocyte differentiation."
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"In addition to cold and beta3-agonists, PPARgamma agonists can also induce beige cell differentiation in the mouse, which was shown to require PRDM16."
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"Ligand activated PPARgamma induces adipocyte differentiation, inhibits the production of proinflammatory mediators, and suppresses aromatase activity."
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"Interestingly, PPARgamma agonists are known to promote white adipose tissue differentiation and expansion in pre-adipocytes and stimulate lipogenesis 39, similar to what we now observed in HSC."
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"These results suggest that PPARgamma agonists promote neuro-glial differentiation by modulating distinct stemness and differentiation gene expression profile in NSCs."
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"Because PPARgamma cleavage strongly correlated with metabolic changes in TAMs and the cleavage of PPARgamma impairs its transcriptional activity, we sought to determine whether PPARgamma depletion would promote TAM differentiation and recapitulate the metabolic reprogramming observed in differentiating TAMs."
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"Interestingly, PPARgamma has been reported to crosstalk with activin A : on the one hand, activin A treatment can inhibit PPARgamma expression in 3T3-L1 preadipocytes, leading to reduced adipocytes differentiation [XREF_BIBR]; on the other hand, PPARgamma activation by rosiglitazone can decrease follistatin (activin A antagonist) mRNA levels in rat intestinal epithelial cells, leading to the gain-of-function of activin A, which mediates the effects of TZDs on cell proliferation [XREF_BIBR]."
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"PPARgamma Regulates Trophoblast Proliferation and Promotes Labyrinthine Trilineage Differentiation."
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"Tributyltin, triphenyltin, and, to a lesser extent, dibutyltin, are PPARgamma ligands that can induce adipocyte differentiation ([XREF_BIBR] (review) and more recent primary literature [XREF_BIBR, XREF_BIBR - XREF_BIBR])."
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"Our new findings show that activation of normal human B cells increases PPARgamma protein levels, and that PPARgamma activation increases cell differentiation."
PPARG activates cell differentiation. 1 / 5
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bel
"expression of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits transformed growth of NSCLC and promotes epithelial differentiation of these cells."
Transcriptionally active PPARG activates cell differentiation. 3 / 3
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bel
"Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor for eicosanoids that promotes differentiation of human epithelial and mesenchymal cells in vitro and in vivo."
bel
"PPARg was shown to be a differentiation-promoting transcription factor in adipogenesis (Fajas et al., 2001; Rosen and Spiegelman, 2001). Both caveolin-1 and -2 levels increase dramatically during differentiation of preadipocytes to adipocytes (Scherer et al., 1994, 1997) Human MCF-7 breast adenocarcinoma and human HT-29 colon adenocarcinoma cells"
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"Activation of PPARG also induces differentiation of colon cancer cells"
Modified PPARG activates cell differentiation. 2 / 2
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"Our results strongly suggest that PPARgamma expression induces CD36 expression and adipocyte differentiation gene activation in the process of atherosclerosis and might be one of the crucial events in SMC derived foam cell formation."
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"In contrast, treatment with the PPARgamma agonist rosiglitazone or overexpression of PPARgamma induced early expression of MAP2 and accelerated the neuron differentiation compared with the mock control (XREF_FIG)."
PPARG bound to RXR activates cell differentiation. 1 / 1
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"The PPARgamma and RXR complex promotes the expression of target genes and adipocyte differentiation."
PPARG bound to anandamide activates cell differentiation. 1 / 1
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"AEA can also bind to PPARgamma to promote adipocyte differentiation XREF_BIBR, a well-known property of PPARgamma agonists."
PPARG bound to GSK3B activates cell differentiation. 1 / 1
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"PPARgamma interacts with GSK3-beta to induce the differentiation factor C/EBPalpha and this leads to the production of adiponectin."
PPARG bound to CACUL1 activates cell differentiation. 1 / 1
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"In this study, we found that CACUL1 binds to PPARgamma and represses its transcriptional activity via opposite regulation of SIRT1 (a deacetylase for histone H3K9) and LSD1 (a demethylase for H3K9) at the PPARgamma target promoter, likely resulting in decreased adipogenic differentiation of murine 3T3-L1 preadipocytes and human ADSCs."