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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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PPARG activates PPARG. 10 / 91
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"Therefore it was possible that relaxin was increasing the expression of PPARgamma or increasing the stability of PPARgamma protein."
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"Interestingly, valsartan did not increase PPAR-gamma messenger RNA expression per se but enhanced the transcriptional activity of PPAR-gamma in mature adipocytes; this enhancement was accompanied by upregulation of the PPAR coactivator (PGC)-1alpha."
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"In conclusion, the present study demonstrates that Ang II induces PPARgamma expression and ligand mediated PPARgamma activity via AT2 receptor activation, which appears to be a crucial process in AT2 receptor mediated neurite outgrowth."
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"The initial step of this pathway involves ligand dependent SUMOylation of the PPARgamma ligand binding domain, which targets PPARgamma to nuclear receptor corepressor (NCoR)-histone deacetylase-3 (HDAC3) complexes on inflammatory gene promoters."
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"Cells were treated with the RSG significantly increased PPARgamma protein level, while CD36 protein level was also highly regulated."
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"Besides, coexpression of PPARgamma with SREBP1c increases the transcriptional activity of PPARgamma [XREF_BIBR]."
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"We have recently shown that SENP2 desumoylates PPARgamma and dramatically increases the activity of PPARgamma."
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"In this context, the recent evidence that deacetylation of PPARgamma at Lys268 and Lys293 by the NAD dependent deacetylase sirtuin 1 (SIRT1) promotes the recruitment of PRDM16 to PPARgamma suggests a new pathway through which WAT browning could be induced 90."
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"Furthermore, curcumin increases the expression of PPARgamma and promotes nuclear translocation of PPARgamma in IEC-6 cells (XREF_FIG) and these results confirmed the previous reports that curcumin activated PPARgamma which was regarded as PPARgamma agonist [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"The initial step of this pathway involves ligand dependent sumoylation of the PPAR-gamma ligand binding domain, which targets PPAR-gamma to nuclear receptor corepressor (NCoR)-histone deacetylase-3 (HDAC3) complexes on inflammatory gene promoters."
PPARG bound to RXR activates PPARG. 2 / 2
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bel
"Retinoids, or vitamin A analogs, are among the most promising chemopreventive agents for breast cancer (Table I). Two classes of retinoid receptors, RARand RXR, bind retinoids and mediate transcriptional regulation of genes that control cellular proliferation, differentiation, and apoptosis (52). RXR is able to interact with many other factors such as vitamin D receptor (VDR), peroxisome proliferator- activator receptor (PPAR), thyroid hormone receptor, and COUP (Fig. 1). Retinoids have been shown to inhibit the growth and invasiveness of breast cancer cells in vitro and in vivo ("
bel
"Page 12"
PPARG bound to anandamide activates PPARG. 2 / 2
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"Anandamide can bind PPARgamma ligand binding domain directly and induce transcriptional activation of PPARgamma in different cell types."
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"Altogether, these data indicate that anandamide binds PPARgamma and induces cellular PPARgamma signaling."
PPARG bound to RXRA activates PPARG. 2 / 2
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bel
"Foxo1 inhibited the DNA binding activity of a PPARgamma/retinoid X receptor alpha heterodimeric complex."
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"(LPL) gene. A conserved DNA recognition element (-171 to -149 bp) within the promoter functions as a transcriptional enhancer when bound by the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2)/retinoid X receptor alpha (RXRalpha) heterodimer"
PPARG bound to NOCT activates PPARG. 1 / 1
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"NOC and a mutated form, which lacks deadenylase activity, bind to PPAR-gamma and markedly enhance PPAR-gamma transcriptional activity."
Modified PPARG activates PPARG. 1 / 1
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"Although precise mechanisms underlying PPARgamma regulation by BPA and down-regulation of FSH induced aromatase by overexpression of PPARgamma in the presence of BPA in human granulosa cells are uncertain, some key observations in other systems may give insight into these regulatory processes."
PPARG bound to TFPI2 activates PPARG. 1 / 1
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"In the presence of rosiglitazone, PP5 translocates to the nucleus, binds to PPARgamma and RUNX2, and dephosphorylates both factors, resulting in activation of PPARgamma adipocytic and suppression of RUNX2 osteoblastic activities."
PPARG bound to RXRalpha activates PPARG. 1 / 1
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"We demonstrate that recurrent alterations in PPARgamma and RXRalpha heterodimer lead to enhanced PPARgamma signaling, reinforcing the importance of this pathway in bladder cancer biology."