IndraLab

"We hypothesized that HPCA brings PKCα to PDK1, after which PDK1 activates PKCα."

"For example , PDK1 activates AKT1 , PKCalpha and other AGC kinases by phosphorylation at key sites ."

"One of the most studied events controlled by ptdins(3,4,5)p3, comprises the activation of a of agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regulating physiological processes relevant to metabolism, growth, proliferation and survival. Here, we review recent biochemical, genetic and structural studies on the 3-phosphoinositide-dependent protein kinase-1 (pdk1), which phosphorylates and activates the agc kinase members regulated by pi 3-kinase. We also discuss whether inhibitors of pdk1 might have chemotherapeutic potential in the treatment of cancers in which the pdk1-regulated agc kinases are constitutively activated."

"For example, PDK1 activates AKT1, PKCα and other AGC kinases by phosphorylation at key sites."

"In TP MO, the notable protein regulator was detected to be PDPK1 (domain- Pkinase) that activates PRKCE (domain- Pkinase) and PRKCA."

"We hypothesized that HPCA brings PKCalpha to PDK1, after which PDK1 activates PKCalpha."

"Modified assertion"

"Modified assertion"

"Modified assertion"