IndraLab

Statements

NTRK1 activates MEK. 4 / 4
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"Conversely, in BI-ALCLs and cALCLs there was an enrichment in genes involved in the neurotrophin signaling pathway (NTRK1, NTRK2, NTF3, NGF), which in turn activates the JAK/STAT, PI3K/Akt and MEK/ERK signaling cascades to promote cell proliferation, differentiation and survival [52,53]."
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"Overexpression of TrkA promoted growth and metastatic potential of xenografted breast cancer cells by activating the MEK and PI3K pathways and enhancing resistance to anoikis [XREF_BIBR]."
28679437
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"Reduction of either GIPC1 or APPL1 decreased signaling by the TrkA receptor to MEK, ERK and Akt."
20600589
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"In fact, 85-90% of papillary carcinomas possess RET, NTRK1, BRAF or RAS mutations that induce MEK and ERK signaling."
18701481
Kinase-active NTRK1 activates MEK. 1 / 1
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"APPL1 and TrkA co-immunoprecipitated in sympathetic neurons. Reduction of APPL1 or GIPC1 protein levels suppressed nerve growth factor (NGF)-dependent MEK, extracellular signal-regulated kinase, and Akt activation and neurite outgrowth in PC12 cells."
17000777