IndraLab

Statements

NTRK1 activates ERK. 10 / 63
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"For example, in PC12 cells, activated EGFR rapidly undergoes the clathrin based endocytosis and the following degradation, whereas activation of TrkA, a receptor for NGF, induces its translocation to long lived signalling endosomes, where TrkA avoids degradation and mediates sustained ERK activation 59."
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"Finally, because Trk activates the extracellular signal regulated kinase pathway in Aplysia sensory neurons, we examined whether this pathway mediates the injury induced changes."
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"The mechanism involved TrkA dependent activation of extracellular signal regulated kinase (ERK1/2) but not phosphatidylinositol 3-kinase (PI3K)/Akt, and de novo protein synthesis."
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"To investigate whether trkA activates the Erk1/2 signaling pathway during responses to NGF, cells were incubated 60 min with the Erk1/2-specific inhibitor, PD-98059 (30 lmol/L, apical and basolateral; 9900L, Cell Signaling, Danvers, MA) or DMSO (0.06%)."
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"ApTrkl, a Trk like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons."
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"Ntrk1 promoted mesangial cell proliferation and inflammation in MsPGN rats by activating the STAT3 and p38/ERK MAPK signaling pathways."
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"In fact, 85-90% of papillary carcinomas possess RET, NTRK1, BRAF or RAS mutations that induce MEK and ERK signaling."
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"TrkA activated cell death does not require p38, JNK or Erk1/2 kinases but does require activation of class III PI-3 kinase and is blocked by the casein kinase 1 (CK1) inhibitor, D4476."
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"In the present study, we investigated the possible involvement of TrkA in alpha 2 -ARs induced modulation of ERK1/2 and Akt cascades and differentiation."
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"Ras and ERK is activated by sAPPalpha, its secretase ADAM17, and neurotrophin Trk receptors."
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NTRK1 bound to NGF activates ERK. 2 / 2
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"The binding of NGF to TrkA activates the PI3K-Akt (phosphatidylinositol 3-kinase-Akt) and Raf-MEK-ERK (Raf-MAPK and extracellular signal regulated kinase kinase-extracellular signal regulated kinase) signalling pathways, which promote the growth and survival of sympathetic neurons."
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"Binding of NGF to the TrkA receptor in PC12 cells activates the ERK family of MAPKs via two small GTPases, Ras and Rap1."
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Kinase-active NTRK1 activates ERK. 1 / 1
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"APPL1 and TrkA co-immunoprecipitated in sympathetic neurons. Reduction of APPL1 or GIPC1 protein levels suppressed nerve growth factor (NGF)-dependent MEK, extracellular signal-regulated kinase, and Akt activation and neurite outgrowth in PC12 cells."
17000777
Mutated NTRK1 activates ERK. 1 / 1
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"Light induced optogenetic TrkA mutants differentially activate the ERK and PLCgamma pathways."
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