"The selective interaction of gambogic amide with the cytoplasmic juxtamembrane domain of TrkA triggers the phosphorylation of TrkA at tyrosine residues Y490 and Y751, elicits AKT and MAPK activation and prevents neuronal cell death XREF_BIBR."
"TrkA mediated activation of Erks and PLC-gamma1 and p75NTR mediated c-jun activation have been proposed to contribute to the pronounced pain observed upon NGF administration, via the opening of TRPV1 channels XREF_BIBR, XREF_BIBR, XREF_BIBR."
"It is known that TrkA triggers the MAPK and ERK1, PI-3 K/Akt, PLCgamma and PKC and cAMP and PKA pathways, and membrane ER triggers the MAPK and ERK1, PKA, Akt and PKB or PKC pathway."
"Given that stimulation of TrkA by NGF induces auto-phosphorylation of this receptor and promotes ERK1/2 activation, we thought it likely that NGF and TrkA interactions might differentially activate downstream signaling between the 2 phenotypes."
"When exposed to nerve growth factor (NGF), PC12 cells transition from a proliferative to a differentiated state, which is manifested as the induction of neurite outgrowth driven by TRKA mediated activation of the ERK MAP kinase pathway [XREF_BIBR]."
"Expectedly, the withdrawal of NGF attenuated endogenous TrkA mediated ERK activation; the addition of PACAP rapidly induced ERK phosphorylation to levels that appeared comparable with those from endogenous TrkA activation within the first hour of treatment."
"In our previous study, we revealed that the L. platyphylla extract contains spicatoside A ( xref ), a steroidal saponin that exerts a neurotrophic effect by inducing neurite outgrowth in PC12 cells and by inducing NGF synthesis in astrocytes through TrkA receptor-mediated PI3-kinase and ERK1/2 activation of CREB, which regulates neuronal function and LTP [ xref ]."
"Erk is activated by TrkA phosphorylation and turns on nuclear effectors involved in gene transcription."
"Importantly, proNGF activates TrkA tyrosine phosphorylation, induces Erk and Akt activation, and causes PC12 cell differentiation."
"Whereas ERK1/2 activated by classical receptor tyrosine kinase growth factor receptors or G protein-dependent GPCR signaling is able to translocate to the nucleus and elicit a transcriptional response[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"