"Noteably, NRAS knockdown further enhanced inhibition of proliferation in the absence of KRAS (XREF_FIG D)."
"It is also possible that NRAS may activate different signaling pathways to KRAS and HRAS; an idea supported by the observation that NRAS has greater transforming activity than KRAS in experimental models of melanoma."
"In contrast to nonresistant cells, NRAS inhibition alone was sufficient to significantly impair proliferation in resistant cells, and NRAS knockdown only slightly and nonsignificantly induced KRAS upregulation."
"Taken together, these results show that signaling by H-Ras and N-Ras, but not K-Ras, are required to promote PGA 1 -induced apoptosis."
"Such Raichu-KRas probe has been recently used to document the specific activation of K-Ras but not H-Ras or N-Ras on late endosomes thus identifying a mechanism for intracellular signal propagation [XREF_BIBR]."