A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

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"Tuftelin Is Required for NGF Induced Differentiation of PC12 Cells."
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"During NGF induced differentiation there is a predominance of N-type Ca2+ channels in growth cones, while Ca2+ stores are of minor importance in these structures."
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"It has been established that NGF induces cell differentiation and neurite outgrowth via the TrkA receptor XREF_BIBR XREF_BIBR."
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"NGF supports differentiation and survival of BFCNs in vitro and in vivo."
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"Then, additional steps were applied to enforce a local false discovery rate of < 5% across the 5 mutant HGprt - cell lines both before and after NGF induced differentiation."
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"Nerve growth factor (NGF) which is an essential contributor to neuronal differentiation has shown high pharmacological potential for the treatment of central neurodegenerative diseases such as Alzheimer 's and Parkinson 's."
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"First, in our experimental conditions iNOS expression occurs as early as 3 hr after the exposure to the combined NGF and TNFalpha treatment [XREF_BIBR], earlier than any morphological differentiation induced by NGF."
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"Nerve growth factor (NGF) in particular supports multiple aspects of cholinergic development and differentiation, including increasing the number and soma size of choline acetyltransferase (ChAT)-positive neurons and promoting neurite outgrowth and ChAT activity in neonatal septum, hippocampus and neocortex."
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"Nerve growth factor (NGF) promotes neuronal survival and differentiation and stimulates neurite outgrowth."
NGF bound to NTRK1 activates cell differentiation. 5 / 5
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"NGF binding to its protein kinase receptor TrkA is known to induce neurite outgrowth and neural cell differentiation."
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
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"Similar mechanisms promoting tumoral cell survival or counteracting neuronal differentiation may be also involved in NB where NGF and TrkA interaction induced differentiation of tumour cells (Eggert et al, 2000)."
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"For example, in PC12 cells, EGF stimulation of EGFR leads to transient Erk phosphorylation and cell proliferation, whereas NGF binding to TrkA leads to sustained Erk phosphorylation and cell differentiation."
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"NGF binds to TrkA receptors and induces differentiation into sympathetic ganglia."
NGF bound to TrkA receptors activates cell differentiation. 1 / 1
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"NGF binds to TrkA receptors and induces differentiation into sympathetic ganglia."
NGF bound to HCLS1 activates cell differentiation. 1 / 1
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"NGF, which can bind to endogenous p75, did not induce differentiation but enhanced the EGF induced response, leading to differentiation of almost all cells."