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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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NGF activates ERK. 10 / 454
| 1 123 314
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"Indeed, sustained activation of ERK1/2 by NGF induces miR-221 and miR-222 in PC12 cells [ xref ]."
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"Since both moxonidine and NGF separately activated ERK, we anticipated that the combination of moxonidine and NGF would produce an additive or synergistic effect."
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"Preincubation of NGF with anti-NGF Ab inhibited NGF induced activation of MAPK and p90rsk."
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"The observed off-target actions of SQ22,536 are specific to cAMP signaling : SQ22,536 does not block the actions of compounds not related to cAMP signaling, including ERK induction by PMA, and ERK activation and neuritogenesis induced by NGF."
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"Several findings suggesting that MAPKs control NCX emerged : (1) A decrease in NCX1 and NCX3 basal expression occurred when JNK or MEK1, the extracellular-signal-regulated kinases 1/2 upstream activator, were pharmacologically blocked, respectively; (2) NGF increased cAMP response element binding 1 (CREB1) and Specificity Protein 1 (Sp1) binding to ncx1 promoter and CREB1 binding to two different sequences close to ncx2 transcription start site on genomic DNA; (3) An up-regulation of NCX1 and NCX3, abrogated upon either MEK1 or p38 blockade, and a down-regulation of NCX2, abolished upon p38 blockade, occurred upon NGF induced MAPK activation."
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"Expression of CMT2B Rab7 Mutants Selectively Impairs NGF Induced Erk1/2 Activation but not Activation of the PI3K and Akt Pathway."
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"We found that NGF increased intracellular H2O2 concentration and activated ERK but failed to affect intracellular superoxide level."
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"We also showed it was not involved in depolarization or NGF induced Erk either."
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"It promotes neuronal differentiation by NGF activating ERK and NF-kappaB pathways [XREF_BIBR]."
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"NGF activates ERK and MAPK and sustained ERK activation plays a key role in centralisation and maintenance of chronic pain."
NGF activates phosphorylated ERK. 7 / 7
| 7
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"Co-treatment with 17-DMAG inhibited NGF mediated increase in p-TrkA, p-AKT, and p-ERK1/2 (XREF_FIG)."
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"In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment."
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"The conjunctive stimulation of NGF and PACAP induced higher intensity of pERK than NGF alone, while inducing pCREB to the same extent with PACAP alone (XREF_FIG dots, XREF_SUPPLEMENTARY)."
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"It also abolished ex vivo neurite outgrowth, whereas NGF treatment, activating pERK signalling, mimicked the injury dependent increase in PCAF phosphorylation."
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"In experiments, the pulse and pulsatile stimulation of NGF induced transient and pulsatile pERK and pCREB (XREF_FIG dots)."
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"NGF, PACAP, EGF, and anisomycin induced distinct temporal patterns and combinations of pERK, pJNK, pp38, and pCREB and the IEGs (XREF_FIG)."
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"The same NGF stimulus caused significant cell-to-cell variation of pERK and pAKT signals, placing cells on both sides of the boundary, producing proliferating and differentiating subpopulations."
NGF bound to NTRK1 activates ERK. 4 / 4
| 4
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"Binding of NGF to trkA leads to activation of the p44/42 MAPK signaling pathway, promotes cancer cell growth, increases the invasiveness and metastasis and eventually mediates nerve invasion [XREF_BIBR]."
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"Evidence suggests that NGF binding to TrkA leads to the activation of Ras and ERK and PI3K and Akt downstream pathways XREF_BIBR."
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"NGF that is released from the neural tissue may stimulate epithelial cancer cell growth and may mediate nerve invasion through its interaction with TrkA, an NGF specific receptor; binding of NGF to TrkA leads to the activation of the p44/42 MAPK signaling pathway and the upregulation of MMP-2, a proinvasive mediator."
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"The binding of NGF to TrkA leads to the activation of the p44/42 MAPK signaling pathway, the promotion of cancer cell growth, increased invasiveness and metastasis, and eventually PNI mediation [XREF_BIBR]."
NGF activates ERK. 1 / 1
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"NGF induces prolonged activation of the Shc/MAP kinase pathway and phospholipase Cgamma compared with PDGF-BB."