"Indeed, sustained activation of ERK1/2 by NGF induces miR-221 and miR-222 in PC12 cells [ xref ]."
"Since both moxonidine and NGF separately activated ERK, we anticipated that the combination of moxonidine and NGF would produce an additive or synergistic effect."
"Preincubation of NGF with anti-NGF Ab inhibited NGF induced activation of MAPK and p90rsk."
"The observed off-target actions of SQ22,536 are specific to cAMP signaling : SQ22,536 does not block the actions of compounds not related to cAMP signaling, including ERK induction by PMA, and ERK activation and neuritogenesis induced by NGF."
"Several findings suggesting that MAPKs control NCX emerged : (1) A decrease in NCX1 and NCX3 basal expression occurred when JNK or MEK1, the extracellular-signal-regulated kinases 1/2 upstream activator, were pharmacologically blocked, respectively; (2) NGF increased cAMP response element binding 1 (CREB1) and Specificity Protein 1 (Sp1) binding to ncx1 promoter and CREB1 binding to two different sequences close to ncx2 transcription start site on genomic DNA; (3) An up-regulation of NCX1 and NCX3, abrogated upon either MEK1 or p38 blockade, and a down-regulation of NCX2, abolished upon p38 blockade, occurred upon NGF induced MAPK activation."
"Expression of CMT2B Rab7 Mutants Selectively Impairs NGF Induced Erk1/2 Activation but not Activation of the PI3K and Akt Pathway."
"We found that NGF increased intracellular H2O2 concentration and activated ERK but failed to affect intracellular superoxide level."
"We also showed it was not involved in depolarization or NGF induced Erk either."
"It promotes neuronal differentiation by NGF activating ERK and NF-kappaB pathways [XREF_BIBR]."
"NGF activates ERK and MAPK and sustained ERK activation plays a key role in centralisation and maintenance of chronic pain."