"We found that II-1beta, but not NGF, promotes fibroblasts ' survival and that NGF stimulates trkA receptor expression, down regulates TFG-alpha, and has no effect on TNF-beta immunoreactivity."
"Furthermore, induction of trk expression by NGF suggests that neurotrophin mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors."
"NGF mediated neuronal differentiation was observed solely in trkA expressing B104 derived clones and was characterized by reduced cell growth, activation of NGF regulated genes, and downregulation of the endogenous low-affinity NGF receptor gene (gp75NGFR)."
"Exogenous NGF delivered to DRG for 2 weeks partially reversed the reduction of TrkA expression as well as atrophy of TrkA immunoreactive neurons."
"Exogenous NGF slightly increased pTrkA levels, and these effects were inhibited with the addition of the anti-TrkA-neutralizing antibody (XREF_SUPPLEMENTARY)."
"Recent evidence indicates that NGF upregulates the expression of both trk and p75 in responsive neurons including rat dorsal root ganglion (DRG) neurons."
"NGF can upregulate the expressions of p75 and trkA mRNA in asthmatic rats, and then may promote their role in the airway neuronal inflammation in asthma."
"A possibly related phenomenon is that, in vitro, NT-3 stimulates predominantly branching of TrkC expressing neurons, whereas NGF stimulates predominantly elongation of TrkA expressing neurons [XREF_BIBR]."
"Rasa2 and TrkA expression is upregulated by NGF stimulation."