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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

NF1 leads to the phosphorylation of MDM2 on S166. 1 / 1

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bel

"HDM2 phosphorylated at serine 166 was readily detected in cycling BJ cells (Figure 6B). However, HDM2 phosphorylation levels were significantly reduced in cells treated with a PI3K inhibitor and were reduced to an even greater extent in cells exposed to an activated Raf allele for 48 hr, or in NF1KD cells."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...