A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

| 2 282
reach
"In conclusion, we show that KLK6 is a proliferative factor in NSCLC that might act by inducing c-Myc synthesis, which in turn modulates specific components of the cell cycle machinery to promote cell cycle progression."
reach
"Myc downregulation, on the other hand, causes cells to exit the cell cycle and undergo differentiation [XREF_BIBR]."
reach
"c-Myc is upregulated following T cell activation and has been demonstrated by several groups to induce cell cycle progression and glycolytic metabolism."
reach
"Nonetheless, the over-expression of aurora kinase genes, in combination with over expression of cell cycle drivers such as cyclin E and Myc, is a recipe for unequal chromosome allocation to daughter cells, and cytoplasmic fragments."
reach
"Similarly, Prdm1 directly represses c-myc expression in macrophages and sebaceous gland progenitors to arrest cell cycle progression, but c-myc is not a target in T cells."
reach
"Moreover, Myc antagonizes the activity of cell cycle inhibitors as p21 and p27 through different mechanisms."
reach
"AKT activation via growth factors promotes c-myc transcription and accelerates cell cycle progression through enhanced expression of D cyclins, and minimizes negative regulators of the cell cycle process such as p21Cip1 and p27Kip1 resulting in a faster exit from the G0 phase XREF_BIBR, XREF_BIBR."
reach
"c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins."
reach
"In breast cancer estrogen can independently regulate the expression and function of the proto-oncogene c-Myc followed by a rapid activation of the G1 CDK, CDK2, to induce cell cycle progression [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
reach
"Myc can transcriptionally downregulate cell cycle inhibitors such as p21, and also increase the expression of positive regulators namely the cyclin D, by mechanisms including transcription and translation [XREF_BIBR, XREF_BIBR]."
Transcriptionally active MYC activates cell cycle. 3 / 3
2 1 |
bel
"from full text - Table 2"
bel
"from full text - Table 2"
bel
"The c-Myc oncoprotein is strongly induced during the G0 to S-phase transition and is an important regulator of cell cycle entry."
Mutated MYC activates cell cycle. 1 / 1
| 1
reach
"MYC mutation or dysregulation can cause a cascade of expression changes of miRNAs and genes and lead to abnormal cell cycle and apoptosis functions."
MYC bound to PIAS2 activates cell cycle. 1 / 1
| 1
reach
"Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15 (INK4b), and how TGF-beta is able to unblock Myc dependent repression of Miz-1."
MYC bound to MAX activates cell cycle. 1 / 1
| 1
reach
"The MYC and MAX heterodimer can also support continued cell cycle progression through the repression of multiple CKIs, including p15, p18, p21, and p27 [XREF_BIBR]."
Modified MYC activates cell cycle. 1 / 1
| 1
reach
"XREF_BIBR MYC overexpression also increases the expression of glucose transporter 1, pyruvate kinase muscle isozyme M2 (PKM2) and lactate dehydrogenase, and cell division cycle 25A (CDC25A), which are all important glycolytic genes."
MYC bound to BPTF activates cell cycle. 1 / 1
| 1
reach
"Bptf also interacts with Myc to promote cell cycle progression."
MYC bound to HIF1A activates cell cycle. 1 / 1
| 1
reach
"Furthermore, HIF1alpha interacted with Myc or Cdc6 to induce cell cycle arrest in the absence of hypoxic signal XREF_BIBR."