"In conclusion, we show that KLK6 is a proliferative factor in NSCLC that might act by inducing c-Myc synthesis, which in turn modulates specific components of the cell cycle machinery to promote cell cycle progression."
"Myc downregulation, on the other hand, causes cells to exit the cell cycle and undergo differentiation [XREF_BIBR]."
"c-Myc is upregulated following T cell activation and has been demonstrated by several groups to induce cell cycle progression and glycolytic metabolism."
"Nonetheless, the over-expression of aurora kinase genes, in combination with over expression of cell cycle drivers such as cyclin E and Myc, is a recipe for unequal chromosome allocation to daughter cells, and cytoplasmic fragments."
"Similarly, Prdm1 directly represses c-myc expression in macrophages and sebaceous gland progenitors to arrest cell cycle progression, but c-myc is not a target in T cells."
"Moreover, Myc antagonizes the activity of cell cycle inhibitors as p21 and p27 through different mechanisms."
"AKT activation via growth factors promotes c-myc transcription and accelerates cell cycle progression through enhanced expression of D cyclins, and minimizes negative regulators of the cell cycle process such as p21Cip1 and p27Kip1 resulting in a faster exit from the G0 phase XREF_BIBR, XREF_BIBR."
"c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins."
"In breast cancer estrogen can independently regulate the expression and function of the proto-oncogene c-Myc followed by a rapid activation of the G1 CDK, CDK2, to induce cell cycle progression [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
"Myc can transcriptionally downregulate cell cycle inhibitors such as p21, and also increase the expression of positive regulators namely the cyclin D, by mechanisms including transcription and translation [XREF_BIBR, XREF_BIBR]."