IndraLab

Statements

Kinase-active MET leads to the phosphorylation of SHC1 on Y427. 1 / 1
1 |
bel
"After stimulation of the HGF receptor, Shc is phosphorylated on Y317VNV, generating an high affinity binding site for Grb2 (Kd = 15 nM). This duplicates the high affinity binding site for Grb2 present on the HGF receptor (Y1356VNV)."
7731718
MET phosphorylates SHC1. 1 / 1
| 1
sparser
"Some of the InlB- and HGF-signaling events occurring downstream from the initial interaction with HGF-R have been identified, including HGF-R tyrosine phosphorylation, recruitment and activation of Gab1, Cbl and Shc, and formation of signaling complexes containing these adapters and the p85 subunit of PI 3-kinase ( xref )."
15337781
MET phosphorylates SHC1 on Y427. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available