IndraLab

Statements

MDM2 increases the amount of MDM2. 10 / 89
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"We also found that Mdm2 indeed plays a causal role in the process, since simultaneous deletion of one Mdm2 allele to reduce Mdm2 levels rescued defective Atm activation."
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"To the contrary, MDM2 expression can be enhanced by activated p53 via induction of MDM2 promoter activity or by increased MDM2 protein stabilization."
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"As expected, the MDM2 vector induced MDM2 protein overexpression (XREF_FIG)."
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"A single nucleotide polymorphism (SNP) in the promoter region of MDM2, SNP T309G (rs2279744), has been identified and was demonstrated to up-regulate the expression of MDM2 via a greater affinity for the SP1 transcription factor."
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"As shown in XREF_FIG, the expression of MDM2 in A549 cells was upregulated to 1.5 times that in the negative control group (P = 0.003) after inhibitor-miR1273f transfection, and mimic-miR1273f transfection significantly downregulated the expression of MDM2 to 2/3 of that in negative control group (P = 0.035)."
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"A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T> G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer."
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"Notably, ATM mutations and MDM2 polymorphisms causing aberrant MDM2 expression have been shown to harbor prognostic relevance in CLL [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Recent data suggested that MDM2 gene polymorphisms may contribute to increased MDM2 basal expression and increase cancer susceptibility."
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"Histone demethylase JMJD2C removed the H3K9me3 modification of MDM2 promoter, which promoted the expression of MDM2."
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"In 2004, Bond et al. reported that the GG genotype of MDM2 SNP309 can significantly increase the expression of MDM2 and thereby suppress the p53 pathway (12)."
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Modified MDM2 increases the amount of MDM2. 5 / 5
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"Increase of MDM2 and ARF levels by DNA damage, recombinant ARF adenovirus infection, or inducible MDM2 expression leads to proteasome mediated down-regulation of MDMX levels."
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"Transcription of mdm2 is induced in a p53 dependent manner following gamma irradiation, indicating that p53 regulates mdm2 expression in vivo following a stimulus."
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"When wild-type p53 was overexpressed in estrogen receptor negative tumor cells containing a mutant or no endogenous p53, MDM2 mRNA levels increased significantly, indicating that wild-type p53 positively influences MDM2 mRNA levels in these tumor cells."
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"Recently, MDM2 expression in the basal layer of the epidermis has been shown to induce hyperplasia and premalignant lesions and expression of MDM2 at an early stage of differentiation has been propose[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although Mdm2 protein decreases p53 levels by promoting its protein degradation, increased Mdm2 mRNA expression does not necessarily lead to higher Mdm2 protein levels."
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MDM2-T309G increases the amount of MDM2. 1 / 3
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"XREF_BIBR, XREF_BIBR, XREF_BIBR With this CRISPR and Cas9 technology, we have created the MDM2 T309G in the genomic DNA of human primary RPE (hRPE) cells and found that the MDM2 T309G mutation enhances rabbit vitreous (RV)-induced expression of MDM2 and cell proliferation, 21 but whether this mutation contributes to the pathogenesis of PVR is still unclear."
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Ubiquitinated MDM2 increases the amount of MDM2. 1 / 1
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"It seems likely that the ubiquitinated MDM2 in the cytoplasm is degraded efficiently by the proteasome, thereby decreasing the level of MDM2."
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MDM2 bound to MDM4 increases the amount of ubiquitinated MDM2. 1 / 1
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"Compounds that disrupt the Mdm2-MdmX interaction will result in reduced E3 ligase activity of Mdm2 and MdmX complex consequently reducing the amounts of ubiquitinated Mdm2 and ubiquitinated MdmX and the FRET signals."
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MDM2 phosphorylated on Y276 increases the amount of MDM2. 1 / 1
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"Phosphorylation of Mdm2 tyrosine 276 leads to increased levels of nucleolar Mdm2 and increases binding of Mdm2 to its negative regulator, ARF."
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