A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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MDM2 increases the amount of MDM2. 10 / 71
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"We also found that Mdm2 indeed plays a causal role in the process, since simultaneous deletion of one Mdm2 allele to reduce Mdm2 levels rescued defective Atm activation."
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"In other words, the increase of p53 restored the decrease of MDM2 transcriptional activity caused by XBP1 suppression, resulting in the overall unchanged MDM2 mRNA expression level in XBP1 silenced HCT116 WT cells."
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"In conclusion, we have provided strong evidence that E/R abrogates p53 signaling through the direct induction of MDM2 expression, a cellular attribute that can be reversed in vitro by the inhibition of MDM2."
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"To the contrary, MDM2 expression can be enhanced by activated p53 via induction of MDM2 promoter activity or by increased MDM2 protein stabilization."
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"MI-43 induced the accumulation of p53 and its downstream target genes, Mdm2, p21, Noxa and Puma only in wt p53-containing cells, indicating that disruption of Mdm2-p53 binding increases p53"
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"It has also been reported that the GG type of MDM2 SNP309 can increase the MDM2 level and leads to attenuation of TP53 function."
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"Together, p53 and Mdm2 function in a negative feedback loop, with p53 driving the transcription of mdm2 during times of normal homeostasis and maintaining low levels of p53 protein."
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"A single-nucleotide polymorphism (SNP) in the promoter region of MDM2 (SNP309T> G, rs2279744) has been shown to increase the expression of the MDM2 protein in various cancer types."
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"Mdm2 transgenic mice, in which the Mdm2 transgene was driven from its normal promoter to create an approximately 4-fold elevation in Mdm2 expression, have an increased incidence of cancer, but not until later in life."
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"As expected, the MDM2 vector induced MDM2 protein overexpression (XREF_FIG)."
Modified MDM2 increases the amount of MDM2. 4 / 4
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"Although Mdm2 protein decreases p53 levels by promoting its protein degradation, increased Mdm2 mRNA expression does not necessarily lead to higher Mdm2 protein levels."
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"When wild-type p53 was overexpressed in estrogen receptor negative tumor cells containing a mutant or no endogenous p53, MDM2 mRNA levels increased significantly, indicating that wild-type p53 positively influences MDM2 mRNA levels in these tumor cells."
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"Increase of MDM2 and ARF levels by DNA damage, recombinant ARF adenovirus infection, or inducible MDM2 expression leads to proteasome mediated down-regulation of MDMX levels."
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"Transcription of mdm2 is induced in a p53 dependent manner following gamma irradiation, indicating that p53 regulates mdm2 expression in vivo following a stimulus."
MDM2-T309G increases the amount of MDM2. 1 / 3
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"XREF_BIBR, XREF_BIBR, XREF_BIBR With this CRISPR and Cas9 technology, we have created the MDM2 T309G in the genomic DNA of human primary RPE (hRPE) cells and found that the MDM2 T309G mutation enhances rabbit vitreous (RV)-induced expression of MDM2 and cell proliferation, 21 but whether this mutation contributes to the pathogenesis of PVR is still unclear."
MDM2 bound to MDM4 increases the amount of ubiquitinated MDM2. 1 / 1
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"Compounds that disrupt the Mdm2-MdmX interaction will result in reduced E3 ligase activity of Mdm2 and MdmX complex consequently reducing the amounts of ubiquitinated Mdm2 and ubiquitinated MdmX and the FRET signals."
MDM2 phosphorylated on Y276 increases the amount of MDM2. 1 / 1
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"Phosphorylation of Mdm2 tyrosine 276 leads to increased levels of nucleolar Mdm2 and increases binding of Mdm2 to its negative regulator, ARF."