IndraLab

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MDM2 increases the amount of TP63. 4 / 4
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"Calabro et al. had reported that in contrast to p53, MDM2 upregulates the protein level of p63 [19]."
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"We show here that like p53, the p63alpha and p63gamma isoforms are able to associate with human MDM2 (HDM2). Overexpression of HDM2 increased the steady-state level of intracellular p63 and enhanced its transcriptional activity. Both effects appeared to be counteracted by ARF coexpression. These data indicate that p63 can be activated by HDM2 under conditions in which p53 is inhibited."
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"The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63."
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"In agreement with our observations, it has previously reported that the E3-ubiquitin ligase MDM2 increases the p63 steady-state level in Saos-2 cells, while it exerts completely opposite effects in ot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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Modified MDM2 increases the amount of TP63. 1 / 1
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"Overexpression of HDM2 increased the steady-state level of intracellular p63 and enhanced its transcriptional activity."
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