"These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2 mediated p53 nuclear export, and possible roles of p53 phosphorylation in regulating p53 cellular localization."
"XREF_BIBR, XREF_BIBR Activation of AURKA instigates Mdm2 mediated destabilization and inhibition of p53, XREF_BIBR and AURKB phosphorylates and induces degradation of p53."
"Phosphorylation of p53 is a key mechanism responsible for the activation of its functions in response to various stresses, and it is well documented that MDM2 plays an important role in regulating phosphorylation of p53 ."
"Other studies have also shown that hypoxia stimulates ATR-CHK1 cascade mediated phosphorylation of p53 [XREF_BIBR] and the MDM2 partner, MDMX [XREF_BIBR], resulting in p53 activation."
"On the other hand, Even though no significant change in protein levels for both HIF-1 α and P53 were observed within the 30 minutes after IR, either phosphorylation of p53 or total P53 and mdm2 either phosphorylation of p53 or total P53 and mdm2 might start to increase compared with HIF-1 α ( xref )."
"In (2), the first term denotes phosphorylation of p53 by ATM; the second one, ubiquitination by Mdm2; and the third one, wip dependent dephosphorylation."
"SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival."
"NgBR promotes the ubiquitination of p53 via Akt-mediated MDM2 phosphorylation."
"For example, DNA damaging agents induce and activate p53 primarily through the induction of a number kinases, notably Ataxia telangiectasia mutated kinase (ATM), ataxia telangiectasia RAD3 related kinase (ATR), Chk1 and Chk2 which phosphorylate p53, MDM2, MDMX [XREF_BIBR - XREF_BIBR]."
"HDM-2 inhibitors induce p53 phosphorylation."