IndraLab
Statements
sparser
"On the other hand, Even though no significant change in protein levels for both HIF-1 α and P53 were observed within the 30 minutes after IR, either phosphorylation of p53 or total P53 and mdm2 either phosphorylation of p53 or total P53 and mdm2 might start to increase compared with HIF-1 α ( xref )."
reach
"In addition, cytoplasmic localization of T155E is further enhanced by Hdm2 overexpression, implying that Hdm2 mediated mono-ubiquitination of p53 and Jab1 mediated p53 phosphorylation cooperatively increases the interaction between CRM1 and p53, which ultimately facilitates nuclear export of p53."