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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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MDM2 phosphorylates TP53. 10 / 10
| 3 2 5
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"These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2 mediated p53 nuclear export, and possible roles of p53 phosphorylation in regulating p53 cellular localization."
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"XREF_BIBR, XREF_BIBR Activation of AURKA instigates Mdm2 mediated destabilization and inhibition of p53, XREF_BIBR and AURKB phosphorylates and induces degradation of p53."
rlimsp
"Phosphorylation of p53 is a key mechanism responsible for the activation of its functions in response to various stresses, and it is well documented that MDM2 plays an important role in regulating phosphorylation of p53 [46]."
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"Other studies have also shown that hypoxia stimulates ATR-CHK1 cascade mediated phosphorylation of p53 [XREF_BIBR] and the MDM2 partner, MDMX [XREF_BIBR], resulting in p53 activation."
sparser
"On the other hand, Even though no significant change in protein levels for both HIF-1 α and P53 were observed within the 30 minutes after IR, either phosphorylation of p53 or total P53 and mdm2 either phosphorylation of p53 or total P53 and mdm2 might start to increase compared with HIF-1 α ( xref )."
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"In (2), the first term denotes phosphorylation of p53 by ATM; the second one, ubiquitination by Mdm2; and the third one, wip dependent dephosphorylation."
rlimsp
"SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival."
rlimsp
"NgBR promotes the ubiquitination of p53 via Akt-mediated MDM2 phosphorylation."
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"For example, DNA damaging agents induce and activate p53 primarily through the induction of a number kinases, notably Ataxia telangiectasia mutated kinase (ATM), ataxia telangiectasia RAD3 related kinase (ATR), Chk1 and Chk2 which phosphorylate p53, MDM2, MDMX [XREF_BIBR - XREF_BIBR]."
sparser
"HDM-2 inhibitors induce p53 phosphorylation."
MDM2 leads to the phosphorylation of TP53 at position 20. 1 / 1
| 1
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"In this study, the pro apoptotic effect of PEDV was examined in Vero cells and we observed that PEDV infection increased MDM2 and CBP, promoted p53 phosphorylation at serine 20 and, promoted p53 nuclear translocation, leading to p53 activation in Vero cells."
MDM2 leads to the phosphorylation of TP53 phosphorylated on S20 on S20. 1 / 1
| 1
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"ATM indirectly regulates MDM2 mediated degradation of p53 through phosphorylation of Chk2 which then phosphorylates p53 at Ser 20 to prevent the formation of the MDM2 and p53 complex."
Phosphorylated MDM2 leads to the phosphorylation of TP53 on S15. 1 / 1
| 1
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"It efficiently inhibited the p53 pathway by dephosphorylation of p53 at its transactivating domain Ser15 as well as by dephosphorylation of MDM2."
MDM2 leads to the phosphorylation of TP53 at position 15. 1 / 1
| 1
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"Consequently, miR-24 dependent silencing of MDM2 increased p53 phosphorylation at serine 15."
MDM2 leads to the phosphorylation of TP53 on serine. 1 / 1
| 1
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"In this study, the pro apoptotic effect of PEDV was examined in Vero cells and we observed that PEDV infection increased MDM2 and CBP, promoted p53 phosphorylation at serine 20 and, promoted p53 nuclear translocation, leading to p53 activation in Vero cells."
MDM2 leads to the phosphorylation of TP53 on S15. 1 / 1
1 |
bel
"In contrast, downregulation of Mdm2 by a small interfering RNA (siRNA) approach led to increased levels of p53 lacking phosphorylation at serine 15 and acetylation at lysine 382. "
Modified MDM2 leads to the phosphorylation of TP53. 1 / 1
| 1
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"In addition, cytoplasmic localization of T155E is further enhanced by Hdm2 overexpression, implying that Hdm2 mediated mono-ubiquitination of p53 and Jab1 mediated p53 phosphorylation cooperatively increases the interaction between CRM1 and p53, which ultimately facilitates nuclear export of p53."