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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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MDM2 increases the amount of TP53. 8 / 119
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"Efficient depletion of Mdm2 by siRNA restored the p53 levels, indicating that CDC7 suppression of p53 levels might directly or indirectly involve Mdm2."
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"Under physiological conditions, p53 expression is inhibited by MDM2 dependent proteasomal degradation while its expression is increased in response to stress including hypoxia."
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"Meanwhile, p53 enhances MDM2 transcription, forming an auto-regulatory feedback loop."
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"In its turn, p53 stimulates Mdm2 transcription."
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"In A549 cells, Cr (VI) causes the dissociation of p53 from mdm2, which leads to elevated p53 levels and p53 activation [XREF_BIBR]."
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"p53 could regulate MDM2 transcription through a feedback mechanism, which would give rise to an oscillated expression pattern of both proteins."
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"Mouse double minute (MDM) 2 single nucleotide polymorphism (SNP) 309G allele in the second promoter of MDM2 enhances vitreous induced expression of Mdm2 and degradation of the tumor suppressor protein p53."
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"Several reports have focused on the p53 mediated apoptotic pathway, upon endogenous p53 protein re-expression by the small-molecule MDM2 antagonists (Nutlins) and target genes wich may be involved in p53 dependent apoptosis in MM cells have been identified."
Modified MDM2 increases the amount of TP53. 10 / 10
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"Other target substrates of akt include the transcription factors FKHR and FoxO [XREF_BIBR], which when phosphorylated are inhibited, mdm2, which following phosphorylation translocates to the nucleus and inhibits transcription of p53 target genes and mTOR (mammalian target of rapamycin)."
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"In MDA-MB-435 and C4-2B cancer cells, 12-Chloracetyl-PPD induced G2/M cell cycle arrest, down-regulated mouse double minute 2 (MDM2) expression, up-regulated p53 expression, triggered apoptosis, and stimulated reactive oxygen species production."
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"In this study, we reported that ST induced the inhibition of E6 and E7 viral oncogene and MDM2 expression, while it led to increased levels of p53, which was transiently located to mitochondria."
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"38 HAUSP mediated deubiquitination can result in both the increase in Mdm2 levels promoting p53 degradation and the increase in p53 levels directly."
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"It has also been demonstrated that ARF can significantly activate p53 through sequestering the transcription of MDM2, which then increases the expression of the p53 target gene p21 [XREF_BIBR]."
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"Furthermore, cell survival was restored by expression of Mdm2 in Elavl1-/- cells, suggesting that HuR keeps p53 levels in check in progenitor cells and thereby promotes cell survival."
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"miR-122 by modulating cyclin G 1 / PP2A and MDM2 expression activates and stabilizes p53 protein expression in hepatocellular carcinoma cells [XREF_BIBR] but it is significantly down regulated in PC [XREF_BIBR]."
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"This degradation results in increased MDM2 levels that subsequently reduced p53 levels."
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"Some of these miRNAs are regulated by p53, and their modulation of MDM2 levels upregulates p53 levels and activity, effectively making this part of the negative-feedback loop."
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"We hypothesized that MDM2 cerebral expression does not increase in response to increased p53 expression or increased levels of phospho-p53 (Ser15), an activated form of p53."
Transcriptionally active MDM2 increases the amount of TP53. 2 / 2
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biopax:ctd
No evidence text available
biopax:ctd
No evidence text available
MDM2 increases the amount of mutated TP53. 2 / 2
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"Because tissue culture experiments suggested that Mdm2 could modulate the levels of mutant p53 as well as wild-type p53, the role of Mdm2 in mutant p53 stability in vivo was examined."
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"They also had increased metastasis compared to the p53 null mice, in the absence of Mdm2, which leads to increased mutant p53 levels."
Catalytically active MDM2 increases the amount of TP53. 1 / 1
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bel
"(b) An Mdm2 protein carrying a point mutation (Mdm2C464A) that inactivates its E3 ligase activity still induces p53 synthesis. (Fig 1)"
MDM2-C305F increases the amount of TP53. 1 / 1
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"Corroborating these data, expression of two additional p53 transcriptional target genes Phlda3 and Bax was increased on average 3.9- and 1.7-fold, respectively, in CFU-Es by Mdm2 C305F."
MDM2 increases the amount of TP53 in the chromatin bound to MDM2. 1 / 1
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trips
"Mdm2 inhibits p53 transactivation by forming a p53-Mdm2 complex on chromatin."
MDM2 bound to CDKN2A increases the amount of TP53. 1 / 1
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"It is possible that small changes in p53 levels activated by PIM1 stabilization of the Mdm2 and ARF complex could be driving increases in transcription of p21, or, as our earlier work suggested, that other signaling pathways (i.e., PKC) possibly regulated by PIM1 could be playing a role in modulating p21 mRNA levels."
Phosphorylated MDM2 increases the amount of TP53. 1 / 1
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"Cellular stresses such as irradiation, lead to phosphorylation and dissociation of p53 and MDM2, which allow p53 protein levels to increase."