IndraLab

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MDM2 increases the amount of TP53. 10 / 155
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"Under physiological conditions, p53 expression is inhibited by MDM2 dependent proteasomal degradation while its expression is increased in response to stress including hypoxia."
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"Meanwhile, p53 enhances MDM2 transcription, forming an auto-regulatory feedback loop."
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"In A549 cells, Cr (VI) causes the dissociation of p53 from mdm2, which leads to elevated p53 levels and p53 activation [XREF_BIBR]."
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"P53 could regulate MDM2 transcription through a feedback mechanism, which would give rise to an oscillated expression pattern of both proteins."
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"Under normal condition, p53 is expressed at low amount due to its continuous degradation by its negative regulator MDM2."
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"The levels of MDM2 and p53 are tightly regulated, as they act in a negative feedback loop where p53 induces MDM2 transcription in response to genotoxic stress, whereas MDM2 binds, inhibits and directs p53 for proteasomal degradation by ubiquitinylation [XREF_BIBR - XREF_BIBR]."
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"It may be of particular interest to investigate how MDM2 mediated regulation of HUWE1 protein stability contributes to the steady-state p53 levels as well as p53 activation in response to cellular stress."
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"Down-regulation of MDM2 allowed elevated expression and acetylation of p53, which increased p21 levels, leading to decreased cell cycle progression and promoted p53 mediated apoptosis."
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"miR-25, miR-32, miR-661 and miR-339-5p target MDM2 to up-regulate p53 protein levels and function [XREF_BIBR - XREF_BIBR]."
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"Together, IR induced modifications of p53 and Mdm2 stabilize p53 and enhance transcription of p53 regulated proteins."
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Modified MDM2 increases the amount of TP53. 10 / 12
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"Other target substrates of akt include the transcription factors FKHR and FoxO [XREF_BIBR], which when phosphorylated are inhibited, mdm2, which following phosphorylation translocates to the nucleus and inhibits transcription of p53 target genes and mTOR (mammalian target of rapamycin)."
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"In MDA-MB-435 and C4-2B cancer cells, 12-Chloracetyl-PPD induced G2/M cell cycle arrest, down-regulated mouse double minute 2 (MDM2) expression, up-regulated p53 expression, triggered apoptosis, and stimulated reactive oxygen species production."
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"In this study, we reported that ST induced the inhibition of E6 and E7 viral oncogene and MDM2 expression, while it led to increased levels of p53, which was transiently located to mitochondria."
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"Furthermore, cell survival was restored by expression of Mdm2 in Elavl1-/- cells, suggesting that HuR keeps p53 levels in check in progenitor cells and thereby promotes cell survival."
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"miR-122 by modulating cyclin G 1 / PP2A and MDM2 expression activates and stabilizes p53 protein expression in hepatocellular carcinoma cells [XREF_BIBR] but it is significantly down regulated in PC [XREF_BIBR]."
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"We hypothesized that MDM2 cerebral expression does not increase in response to increased p53 expression or increased levels of phospho-p53 (Ser15), an activated form of p53."
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"Our findings indicate a mechanism in which mitogens present in injury sites activate myocardial expression of the negative Tp53 regulator Mdm2, which transiently reduces Tp53 levels and facilitates cell cycle entry (XREF_FIG)."
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"38 HAUSP mediated deubiquitination can result in both the increase in Mdm2 levels promoting p53 degradation and the increase in p53 levels directly."
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"It has also been demonstrated that ARF can significantly activate p53 through sequestering the transcription of MDM2, which then increases the expression of the p53 target gene p21 [XREF_BIBR]."
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"After the addition of LPS, however, MDM2 expression was up-regulated, resulting in the down-regulation of p53 expression."
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MDM2 increases the amount of mutated TP53. 2 / 2
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"Because tissue culture experiments suggested that Mdm2 could modulate the levels of mutant p53 as well as wild-type p53, the role of Mdm2 in mutant p53 stability in vivo was examined."
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"They also had increased metastasis compared to the p53 null mice, in the absence of Mdm2, which leads to increased mutant p53 levels."
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MDM2 bound to TP53 increases the amount of TP53. 2 / 2
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"The p53 level and activity are mainly mediated by ubiquitin E3 ligase Mdm2, which binds directly to p53 and facilitates p53 ubiquitination and proteasomal degradation [XREF_BIBR]."
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"It has been reported that the level and activity of p53 are strictly modulated by the ubiquitin E3 ligase Mdm2, which binds p53 directly and mediates p53 ubiquitination and proteasomal degradation continuously (21)."
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MDM2 bound to CDKN2A increases the amount of TP53. 1 / 1
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"It is possible that small changes in p53 levels activated by PIM1 stabilization of the Mdm2 and ARF complex could be driving increases in transcription of p21, or, as our earlier work suggested, that other signaling pathways (i.e., PKC) possibly regulated by PIM1 could be playing a role in modulating p21 mRNA levels."
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Sumoylated MDM2 increases the amount of TP53. 1 / 1
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"Because Mdm2 negatively regulates the p53 tumor suppressor, such a reduction in Mdm2 sumoylation will tend to increase levels of p53 and p53 's growth inhibitory activity."
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Phosphorylated MDM2 increases the amount of TP53. 1 / 1
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"Cellular stresses such as irradiation, lead to phosphorylation and dissociation of p53 and MDM2, which allow p53 protein levels to increase."
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Catalytically active MDM2 increases the amount of TP53. 1 / 1
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"(b) An Mdm2 protein carrying a point mutation (Mdm2C464A) that inactivates its E3 ligase activity still induces p53 synthesis. (Fig 1)"
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MDM2-C305F increases the amount of TP53. 1 / 1
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"Corroborating these data, expression of two additional p53 transcriptional target genes Phlda3 and Bax was increased on average 3.9- and 1.7-fold, respectively, in CFU-Es by Mdm2 C305F."
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MDM2 increases the amount of TP53 in the chromatin bound to MDM2. 1 / 1
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"Mdm2 inhibits p53 transactivation by forming a p53-Mdm2 complex on chromatin."
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