IndraLab
Statements
reach
"Therefore, although we can not completely rule out possible involvement of Mdm4 for p53 regulation and/or p73 for suppression of T cell proliferation in this study, Mdm2 mediated p53 regulation appears to be of predominant importance for controlling antigen specific T cell proliferation."
reach
"While both Mdm2 Y487A and Mdm2 C462A disrupt p53 degradation and maintain Mdm2 degradation, the location of the Y487 residue, C-terminal of the Mdm2 RING finger domain, should not disrupt zinc coordination, thus proper folding and the structure of the RING domain should remain intact (XREF_SUPPLEMENTARY)."
reach
"While both Mdm2 Y487A and Mdm2 C462A disrupt p53 degradation and maintain Mdm2 degradation, the location of the Y487 residue, C-terminal of the Mdm2 RING finger domain, should not disrupt zinc coordination, thus proper folding and the structure of the RING domain should remain intact (XREF_SUPPLEMENTARY)."