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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MAPK1 increases the amount of DUSP6. 1 / 4

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"As a control, we included wild-type ERK1 and ERK2, both of which produced robust RSK phosphorylation and elevated DUSP6 expression in this setting (XREF_SUPPLEMENTARY)."

25320010

MAPK1 phosphorylated on Y187 and T185 increases the amount of DUSP6. 2 / 2

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biopax:pid

No evidence text available

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biopax:pid

No evidence text available

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MAPK1-G37S increases the amount of DUSP6. 1 / 1

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"For example, both ERK1 G54A and the analogous variant ERK2 G37S had minimal effects on RSK phosphorylation following DOX induction, but produced elevated DUSP6 expression (similar to the kinase-dead ERK variants)."