IndraLab

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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal-regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [ xref – xref ]."

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"Activation of the Akt pathway blocks the apoptotic pathway by negatively regulating the activity of BAD, a member of the Bcl2 family that binds to Bcl2 or Bcl-XL and inhibits their anti-apoptotic activity [XREF_BIBR], and the ASK1 and JNK mediated pro apoptotic pathway via phosphorylation of ASK1 at ser83 that inhibits ASK1 activity [XREF_BIBR]."

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"Phosphorylation of ASK1 Ser83 by AKT attenuates ASK1 kinase activity."

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"It has been shown by others that ASK1 can be phosphorylated at several sites which either up- or down-regulate ASK1 kinase activity."

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"On the basis of our finding that methylation of ASK1 negatively regulates H 2 O 2 -induced activation of ASK1, we next asked whether methylation of ASK1 at Arg 89 affects Ser 83 in vitro and in vivo."

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"Phosphorylation of ASK1 at S83 by Akt and PKB (protein kinase B) and dephosphorylation at S845 by protein phosphatase 5 (PP5) both decrease ASK1 activity."

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"PIM1 phosphorylation of ASK1 decreases ASK1 kinase activity."

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"Inactive IGF-1R does not phosphorylate ASK1 and subsequently does not inhibit ASK1 kinase activity."

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"Interestingly, phosphorylation of human ASK1 Ser83 by Akt is thought to attenuate Ask1 activity and inhibit apoptosis (Kim et al., 2001; Zhang et al., 2005)."

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"A Novel ASK Inhibitor AGI-1067 Inhibits TLR-4-Mediated Activation of ASK1 by Preventing Dissociation of Thioredoxin from ASK1."
MAP3K5 bound to TXN inhibits MAP3K5. 7 / 7
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"Another function of reduced Trx is to bind and inhibit ASK1, whereas oxidized Trx dissociates from ASK1 [43,51,52]. We therefore examined Trx1/ASK1 association as another cellular indicator of the functional redox state of Trx1. In untreated cells in which >95% of Trx1 is reduced (Fig. 4), ASK1 is bound to Trx1 (Fig. 8)."

"Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation"

"Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation"

"Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase kinase kinase family, plays pivotal roles in reactive oxygen species (ROS)-induced cellular responses. In resting cells, endogenous ASK1 constitutively forms a homo-oligomerized but still inactive high-molecular-mass complex including thioredoxin (Trx), which we designated the ASK1 signalosome. Upon ROS stimulation, the ASK1 signalosome unbinds from Trx and forms a fully activated higher-molecular-mass complex"

"Binding of Trx inactivates ASK1 catalytic activity."

"Binding of Trx inactivates ASK1 catalytic activity."

"Another function of reduced Trx is to bind and inhibit ASK1, whereas oxidized Trx dissociates from ASK1 [43,51,52]. We therefore examined Trx1/ASK1 association as another cellular indicator of the functional redox state of Trx1. In untreated cells in which >95% of Trx1 is reduced (Fig. 4), ASK1 is bound to Trx1 (Fig. 8)."
MAP3K5 bound to TXN inhibits MAP3K5. 3 / 3
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"Since thioredoxin is bound to ASK-1 and inhibits the activation of ASK-1 [XREF_BIBR - XREF_BIBR, XREF_BIBR], experiments were carried out to evaluate whether thioredoxin knockdown activates ASK-1 and downstream MAPK signaling pathways in the E47 cells."

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"In resting cells, ASK1 is bound to either thioredoxin or CIB1, two known endogenous inhibitors of ASK1 [26,27]."

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"Since thioredoxin is bound to ASK-1 and inhibits the activation of ASK-1, experiments were carried out to evaluate whether thioredoxin knockdown activates ASK-1 and downstream MAPK signaling pathways in the E47 cells."
MAP3K5 bound to TXN2 inhibits MAP3K5. 3 / 3
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"Trx2, like Trx1 XREF_BIBR, directly binds to ASK1, and forms a complex with ASK1 in mitochondria, inhibiting ASK1 activity XREF_BIBR."

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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [XREF_BIBR - XREF_BIBR]."

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"Since Trx2 bind to Apoptosis signal regulating kinase 1 (Ask1), a major mitogen activated protein kinase kinase kinase (MAPKKK) and inhibits Ask1 phosphorylation and activation, increased binding of Txnip to Trx2 reduces the interaction between Trx2 and Ask1 and induces Ask1 activation for apoptosis."
MAP3K5 bound to CIB1 inhibits MAP3K5. 3 / 3
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"Instead, CIB1 physically associates with ASK1, and thereby prevents ASK1 activation induced by MPP +."

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"Given that CIB1 directly binds ASK1 and thereby inhibits the MPP + -induced activation processes of ASK1, we reasoned that the blockade of ASK1 by CIB1 may be an important part of the mechanism by which CIB1 negatively regulates MPP + -mediated toxicity in dopaminergic neurons."

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"In resting cells, ASK1 is bound to either thioredoxin or CIB1, two known endogenous inhibitors of ASK1 [26,27]."
MAP3K5 bound to TXN inhibits MAP3K5. 3 / 3
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"Oxidative stress causes the oxidation of TRX, which disrupts the ASK and TRX complex, thereby activating ASK1 to induce apoptosis [22]."

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"TXN binds to ASK1 and prevents ASK1 from full activation, thus downregulating the p38 pathway [XREF_BIBR]."

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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [XREF_BIBR - XREF_BIBR]."
MAP3K5 bound to Recombinant Hsp72 inhibits MAP3K5. 1 / 1
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"Recombinant Hsp72 bound directly to ASK1 and inhibited ASK1 activity in vitro."
MAP3K5 bound to GLRX inhibits MAP3K5. 1 / 1
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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [XREF_BIBR - XREF_BIBR]."
MAP3K5 methylated on R89 inhibits MAP3K5. 1 / 1
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"In summary, H 2 O 2 -induced ASK1 activity can be inhibited by PRMT5 methylation of ASK1 at Arg 89, which in turn promotes interaction between ASK1 and Akt and enhances phosphorylation of ASK1 at Ser 83, which inhibits endothelial cells apoptosis."
MAP3K5 bound to TTC5 inhibits MAP3K5. 1 / 1
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"We recently reported that STRAP interacts with ASK1 and subsequently inhibits ASK1 activity."
MAP3K5 bound to CDKN1A inhibits MAP3K5. 1 / 1
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"For examples, cytoplasmic p21 forms a complex with the apoptosis signal regulating kinase 1 (ASK1) and inhibits activation of ASK1 and its substrate SAPK and JNK in the MAP kinase cascade [XREF_BIBR]."
MAP3K5 bound to QARS1 inhibits MAP3K5. 1 / 1
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"we investigated the molecular interaction between human glutaminyl-tRNA synthetase (QRS) and ASK1 and found the Gln-dependent association of the two molecules. While their association was enhanced by the elevation of Gln concentration, they were dissociated by Fas ligation within 5 min. The association involved the catalytic domains of the two enzymes. The ASK1 activity was inhibited by the interaction with QRS as determined by in vitro kinase and transcription assays. Finally, we have shown that QRS inhibited the cell death induced by ASK1, and this antiapoptotic function of QRS was weakened by the deprivation of Gln"
MAP3K5 bound to PPM1L inhibits MAP3K5. 1 / 1
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"Exogenous PP2Cepsilon associated with exogenous ASK1 in HEK-293 cells under non stressed conditions, inactivating ASK1 by decreasing Thr845 phosphorylation."