IndraLab

Statements

SMAD4 inhibits ESR1. 4 / 7
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"IP experiments of MCF-7 cell lysates with anti-ERalpha antibody followed by Western Blotting for ERalpha, showed that SMAD4 knockdown induces a greater retention of ERalpha, so as to be longer expressed, compared to that one obtained in wild type cells."
23053665
reach
"The results confirm that SMAD4 physically interact with ERalpha and expression of SMAD4 is necessary to mediate the bergapten induced ER degradation."
23053665
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"Overexpression of Smad3 enhanced ERalpha induced transcription, while Smad4 alone or in complex with Smad3 inhibited ERalpha transcription activity."
19943940
reach
"Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells."
20734429
Catalytically active SMAD4 inhibits ESR1. 1 / 1
1 |
bel
"Modified assertion"
12576474