IndraLab

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SMAD3 phosphorylates SMAD2. 10 / 13
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"Collagen-I, collagen-III, fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), TGF-beta1, Smad2, Smad3, phosphorylated (p-) Smad2, p-Smad3 and Smad7 proteins were detected by western blotting as previously described."
33456506
sparser
"Here we report that hyper-proliferative human PAH PAVSMC have elevated secretion of TGF-β1 and, to a lesser extent, Activin A, but not Gremlin 1, and significantly reduced Ser 465/467 -Smad2 and Ser 423/425 -Smad3 phosphorylation compared to controls."
30274147
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"Furthermore, both SMAD2 and SMAD3 are activated by phosphorylation, and our results support that patients whose TAFs exhibit a low (<1) pSMAD3/pSMAD2 ratio may be refractory to nintedanib and possibly to other antifibrotic drugs, whereas those with high (>1) pSMAD3/pSMAD2 ratio may elicit positive responses (where pSMAD2 and pSMAD3 refers to phosphorylated SMAD2 and SMAD3, respectively) (Figure 3D)."
34359678
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"Our data showed that both DN-Smad-2 and DN-Smad-3 significantly decreased Smad-2 and Smad-3 phosphorylation (Fig 2, A)."
17418380
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"In the present study, we observed that the TGF-beta1-induced phosphorylation of Smad2 and Smad3 and the TGF-beta1-induced increase in alpha-SMA production were partially dependent on Smad2 and Smad3 and were reversed by knockdown of both Smad2 and Smad3."
29116196
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"Furthermore, xenografts with Stat3 knockdown displayed increased Smad3 transcriptional activity, increased Smad2 phosphorylation and decreased Smad7 expression compared with control xenografts in vivo."
22751114
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"VP also decreased myofibroblast activation and proliferation in UUO kidneys and NRK-49F cells by modulating Smad2 and Smad3 phosphorylation."
33142952
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"In addition, oridonin reduced the levels of Smad2, Smad3, Smad4, PAI-1 and the phosphorylation of Smad2 and Smad3 induced by TGF-beta1 in vitro."
31686852
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"Protein phosphorylation of SMAD 2 and SMAD 3 as well as SMAD 2, SMAD 3, and SMAD 4 levels was measured using western blot analysis in the DFAT cells incubated with or without (vehicle control) 5ng."
28781950
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"CX-4945 treatment had no significant effect on TGFbeta1 induced phosphorylation of S465/467 Smad2 and S423/425 Smad3 (XREF_FIG)."
28468969
SMAD3 leads to the phosphorylation of mutated SMAD2. 1 / 1
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"Similar strategy was applied to generate the phosphorylated wild-type and mutant Smad2 MH2 (241-462), Smad3-MH2 (200-425), and the full-length Smad3 (1-425)."
11779503
SMAD3 phosphorylates SMAD2 on serine. 1 / 1
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"Ligand binding and recruitment of TβRI activates its kinase that phosphorylates the carboxy-terminal serine residue of SMAD2 (SMAD Family Member 2) or SMAD3 (SMAD Family Member 3), which induces oligomerization of SMAD2 or SMAD3 with SMAD4 (SMAD Family Member 4), resulting in nuclear translocation for transcriptional activation or repression of target genes."
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