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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SMAD3 phosphorylates SMAD2. 6 / 6
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"Here we report that hyper-proliferative human PAH PAVSMC have elevated secretion of TGF-β1 and, to a lesser extent, Activin A, but not Gremlin 1, and significantly reduced Ser 465/467 -Smad2 and Ser 423/425 -Smad3 phosphorylation compared to controls."
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"Protein phosphorylation of SMAD 2 and SMAD 3 as well as SMAD 2, SMAD 3, and SMAD 4 levels was measured using western blot analysis in the DFAT cells incubated with or without (vehicle control) 5ng."
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"CX-4945 treatment had no significant effect on TGFbeta1 induced phosphorylation of S465/467 Smad2 and S423/425 Smad3 (XREF_FIG)."
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"In the present study, we observed that the TGF-beta1-induced phosphorylation of Smad2 and Smad3 and the TGF-beta1-induced increase in alpha-SMA production were partially dependent on Smad2 and Smad3 and were reversed by knockdown of both Smad2 and Smad3."
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"Furthermore, xenografts with Stat3 knockdown displayed increased Smad3 transcriptional activity, increased Smad2 phosphorylation and decreased Smad7 expression compared with control xenografts in vivo."
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"The protein levels of alpha-smooth muscle actin (alpha-SMA), type 1 collagen (Col1), Smad2, Smad3, phosphorylated Smad2 (p-smad2), p-smad3 and Smad7 were assessed by Western blot analysis."