IndraLab

Statements

SMAD3 inhibits SMAD2. 10 / 23
| 20
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"These findings showed that a single missense mutation in Smad3 could specifically block TGF-beta signals by preventing activation of both Smad2 and Smad3."
9688538
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"Knockout of Smad3 blocks TGF-beta-induced EMT in primary tubular epithelial cells, and the reduction of Smad2 and Smad3 function is associated with the decreased metastatic potential of breast cancer cell lines in a xenograft model [XREF_BIBR]."
18604456
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"Furthermore, the knockdown of SMAD4 or SMAD2 but not SMAD3 abolished the inhibitory effects of all three activin isoforms on StAR expression."
26001835
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"Additionally, we identify that PRMT1 knockdown results in down-regulation of TGF-beta1, p-Smad2 and p-Smad3, while PRMT1 overexpression activates TGF-beta1, p-Smad2 and p-Smad3."
31607134
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"The location of SMAD2 and SMAD3 in the cytoplasmic and nuclear fractions of RIE-1-TrkB cells block nuclear localization of SMAD2 and SMAD3 in response to TGF-beta."
32340410
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"Knockout of Smad3 blocks TGF-beta-induced EMT in primary tubular epithelial cells, and the reduction of Smad2 and Smad3 functions are associated with the decreased metastatic potential of breast cancer cell lines in a xenograft model [XREF_BIBR]."
21880181
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"These results support that Smad2 but not Smad3 functions as a tumor suppressor in NRP-152 cells, although loss of Smad3 enhanced tumor growth and incidence in the Smad2 deficient cells."
19276350
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"Our data show that during PCMO generation pluripotency marker expression is controlled positively by activin and Smad2 and negatively by TGF-beta and Smad3 signaling, while relief from growth inhibition is primarily the result of reduced TGF-beta and Smad3, and to a lesser extent, activin and Smad2 signaling."
25707005
reach
"Knockdown of Smad2, but not Smad3, led to disruption of pIgR-Smad interactions, suggesting that pIgR plays a direct role in recruiting Smad2 (XREF_FIG)."
22025622
reach
"Depletion of SMAD2, but not SMAD3, significantly abolished the inhibitory effects of TGFbeta1 on the growth of GBM cells, possibly through pSMAD2 mediated increases in cell-cycle inhibitor, p27."
25832460
Mutated SMAD3 inhibits SMAD2. 1 / 1
| 1
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"A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-beta signals."
9688538