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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SMAD2 activates SMAD4. 9 / 15
1 | 2 10
reach
"We have demonstrated that PR-619 suppressed UUO induced upregulation of Smad4 but not TGF-beta receptors, Smad2, or Smad3."
reach
"Furthermore, KLF10 overexpression enhanced the TGFbeta induced Smad2 phosphorylation and increased the transcription of Smad2, but not Smad3 or Smad4 [XREF_BIBR]."
sparser
"For instance, phosphorylated Smad-2 can activate the Wnt/β-catenin signaling pathway independently of Smad-4 through p300 [ xref ]."
signor
"the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4"
reach
"Overexpression of Smad2 increases endogenous Smad4 and TGF-beta 1 expression while heterozygous loss of Smad2 reduces their expression levels, suggesting a concerted action of Smad2 and -4 in regulating TGF-beta signaling during skin development."
reach
"Through analyzing the publicly available algorithms, including TargetScan, miRWalk, and miRanda, we found that several components of TGF-beta signaling, including SMAD2, SMAD4, and TGFBRI, may be potential targets of miR-582-3p, and SMAD2, SMAD4, TGFBRI, and TGFBRII for miR-582-5p (XREF_SUPPLEMENTARY A-S4C)."
reach
"This causes phosphorylation of SMAD2 and SMAD3, two transcription factors that then bind to and activate SMAD4."
reach
"That overexpression of Smad3 and Smad4, but not Smad2, decreased Galectin-3 promoter activity, while Smad3 silencing inhibited the promoter activity clearly indicated that the Galecin-3 promoter activity was responsive to Smad3."
sparser
"We have previously demonstrated that phosphorylated Smad2 can activate the Wnt/β-catenin signaling pathway independently of Smad4 [ xref ]."
SMAD2 bound to SMAD4 activates SMAD4. 3 / 3
3 |
bel
"Phosphorylation of the C-terminal serine residues in R-Smads by type I receptor kinases is a crucial step in TGF-b family signalling (Abdollah et al., 1997; Macias-Silva et al., 1996; Souchelnytskyi et al., 1997). The two most C-terminal serine residues become phosphorylated and, together with a third, non-phosphorylated serine residue, form an evolutionarily conserved SSXS motif in all R-Smads.... TGF-b and activin receptors phosphorylate Smad2 and Smad3, and BMP receptors phosphorylate Smad1, Smad5 and Smad8 (Chen et al., 1998) (Fig. 1). The consequence of R-Smad phosphorylation is the formation of oligomeric complexes with the Co-Smad, Smad4."
bel
"\"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.\""
bel
"Smad7 is known to participate in a negative feedback loop in which TGF- activation results in R-Smad translocation to the nucleus where Smad7 transcription is induced by R-Smad Smad4 complexes and the produced Smad7 protein subsequently inhibits TGF-beta signaling (19, 20)."
SMAD2 phosphorylated on S467 activates SMAD4. 1 / 1
1 |
bel
"\"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.\""
SMAD2 bound to SMAD3 and SMAD4 activates SMAD4. 1 / 1
1 |
bel
"from Figure 1 - Fig 1. The transforming growth factor beta (TGF-b) signaling pathway. TGF-b binds type II TGF-b receptor (TbRII), directly or through TbRIII, inducing association of TbRII with TbRI. TbRII then phosphorylates and activates TbRI, which then phosphorylates Smad2 or Smad3. Phosphorylated Smad2 or Smad3 associates with Smad4 and they translocate into the nucleus, where they activate transcription of target genes. Smad7 inhibits TGF-b signaling by preventing the activation of Smad2 or Smad3 by TbRI."
SMAD2 phosphorylated on S465 activates SMAD4. 1 / 1
1 |
bel
"\"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.\""