IndraLab

Statements

SMAD2 inhibits SMAD2. 10 / 17
| 11 3
reach
"Protein phosphatase PPM1A, which was identified to negatively regulate the activin signaling pathway, can dephosphorylate phospho-SMAD2 and enable SMAD2 to relocate back to the cytoplasm and terminate signal transduction [XREF_BIBR]."
| PMC
sparser
"In this study, we found that miR-582-3p targeted SMAD2, SMAD4, and TGFBRI, and miR-582-5p directly inhibited SMAD2, TGFBRI, and TGFBRII."
30852380
reach
"Besides, we also found that p21-activated kinase 2 (PAK2) can directly phosphorylate Smad2 at Ser417, which interferes with the TβRI-Smad2 association and thus blocks TGF-β-induced Smad2 activation and signaling [93]."
25332839
reach
"Besides, we also found that p21 activated kinase 2 (PAK2) can directly phosphorylate Smad2 at Ser417, which interferes with the TbetaRI-Smad2 association and thus blocks TGF-beta-induced Smad2 activation and signaling [XREF_BIBR]."
25332839
sparser
"To evaluate if PI3K activation was dependent on SMAD2 activation, we assessed if the phosphorylated p85 subunit of PI3K was affected by inhibition of native SMAD2 by DN-SMAD2 after TGFβ treatment."
18769113
reach
"Besides, we also found that p21-activated kinase 2 (PAK2) can directly phosphorylate Smad2 at Ser417, which interferes with the T RI-Smad2 association and thus blocks TGF--induced Smad2 activation and signaling [93] ."
25332839
reach
"These results demonstrate that inhibiting TGF-beta signaling with SB-431542 blocks phosphorylation of Smad2 and Smad3 and prevents nuclear translocation of p-Smad2 and p-Smad3, which ultimately interrupts bladder smooth muscle formation."
23620745
reach
"Smad2 phosphorylation at the linker region inhibits the nuclear accumulation of Smad2 without interfering with the TGF-beta-induced phosphorylation of its COOH-tail."
21626291
reach
"Activation of Ca2 +/calmodulin-dependent protein kinase II (CamKII) also results in Smad2, Smad3 and Smad4 phosphorylation inhibiting TGF-beta-induced nuclear import and transcriptional activity of Smad2, and affecting Smad heteromerization [XREF_BIBR]."
16611366
reach
"Each dose of losartan after bilateral cavernous nerve injury significantly attenuated the up-regulated expression of fibronectin (p < 0.01), pSMAD2 (p < 0.05) and thrombospondin-1 (p < 0.05), and up-regulated total SMAD2 (p < 0.05)."
19375729
Phosphorylated SMAD2 inhibits SMAD2. 1 / 1
| 1
reach
"In this study, LDN repressed phosphorylation of SMAD2 as well as SMAD1/5 and SB inhibited phosphorylation of SMAD1/5 as well as SMAD2 (Fig. 5b)."
30349003
SMAD2 bound to SMAD4 inhibits SMAD2. 1 / 1
| 1
reach
"SMAD7 acts as an inhibitor of SMAD in the TGF-β/SMAD pathway and may prevent TGF-β-dependent SMAD2/SMAD4 complex formation and inhibit SMAD2 accumulation in the nucleus (Figure 4)."
36156927
SMAD2 bound to SMAD4 and SMAD2 inhibits SMAD2. 1 / 1
| 1
reach
"As such, Smad2 targets are activated solely by the Smad2, Smad2, and Smad4 complex, whereas Smad3 targets are activated both by Smad2-Smad3-Smad4 and Smad3-Smad3-Smad4 trimers."
24105267
SMAD2 bound to KLC3 inhibits SMAD2. 1 / 1
| 1
reach
"We show that siRNA loss of LMTK2 not only reduces binding of Smad2 to KLC2 but also inhibits Smad2 nuclear signalling in response to TGFbeta."
21996745
SMAD2 bound to TGIF1 inhibits SMAD2. 1 / 1
1 |
bel
"c-Jun, which enhances the association of Smad2 with the nuclear transcriptional corepressor TG-interacting factor (TGIF), thereby interfering with the assembly of Smad2 and the coactivator p300 in response to TGF-beta signaling"
11371641