A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SMAD2 increases the amount of TGFB1. 3 / 3
| 3
reach
"Enhanced expression of TGF-beta1 could promote SC proliferation and apoptosis, down regulation of cytokines and Smad2, 4."
reach
"The use of LY2109761, a selective inhibitor of TGF-beta1 and Smad2, diphenyliodonium (DPI), and/or astragaloside IV (AST IV is a monomer located in an extract of astragaloside) decreased the NOX4 expression, the level of ROS, and the TGF-beta1 and Smad2 expression, suggesting that inhibitions of the NOX4 and TGF-beta1 and Smad2 pathways downregulate apoptosis in HUVECs 30."
reach
"TGF-beta 1 -induced TTC3 expression was inhibited by the knockdown of SMAD2 and SMAD3."
SMAD2 bound to SMAD3 and SMAD4 increases the amount of TGFB1. 1 / 1
1 |
bel
"a dimeric Smac/DIABLO molecule is required for binding to BIR2, but not to BIR3, which indicates significant differences in the affinity or mechanism by which Smac/DIABLO binds to these domains Figure 5: Association of IAPs with signalling complexes."