IndraLab

Statements

AR activates EP300. 4 / 4
| 3 1
reach
"CBP and p300 increases AR transactivation of the AR in response to androgen or IL-6 (Fronsdal et al., 1998; Debes et al., 2002)."
20541699
reach
"AR S81 phosphorylation has been reported to enhance binding of the histone acetyltransferase EP300 (p300), suggesting that p300 binding and subsequent histone acetylation may drive a positive feedback loop through increased BRD4 recruitment, a subsequent increase in P-TEFb recruitment and further AR S81 phosphorylation."
28062857
reach
"Task 7, ' Passages with GI types (GI evidence passages) ' -- Identification of passages describing GI types, e.g. ' Synergy of FLAP1 and p300 for enhancement of transcriptional activation by beta-catenin, LEF1 and TCF and AR '."
27589962
sparser
"Expression of the coactivators steroid receptor coactivator-1, receptor-associated coactivator-3, and p300 stimulated both agonist-dependent and -independent activation by AR."
11981028
Transcriptionally active AR activates EP300. 1 / 1
1 |
bel
"AR dramatically increased the intrinsic transcriptional activity of the nuclear receptor coactivators glucocorticoid receptor-interacting protein-1 (GRIP1), cAMP response element-binding protein-binding protein, and p300 that are tethered to DNA."
11429409
AR bound to STAT3 activates EP300. 1 / 1
| 1
reach
"The IL6-IL6R signaling leading to activation of the JAK1 - STAT3 pathway is also involved, whereby STAT3 interacts with AR and enables recruitment of p300 to AR transcriptional complex [XREF_BIBR, XREF_BIBR]."
25277175
AR activates EP300. 1 / 1
1 |
bel
"In this study, we describe a novel ligand-dependent transactivation function for AR that is independent of its DNA binding ability. AR dramatically increased the intrinsic transcriptional activity of the nuclear receptor coactivators glucocorticoid receptor-interacting protein-1 (GRIP1), cAMP response element-binding protein-binding protein, and p300 that are tethered to DNA."
11429409