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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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KRAS activates MAPK1. 2 / 9
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"Another one is that mutant Kras-activated ERK2 directly phosphorylates SNAIL [ xref ]."
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"By the nanoimmunoassay (NIA), KRAS is found to activate the protein ERK2, whereas ERK1 activation is found in non-KRAS-associated human lung tumors."
KRAS-G12D activates MAPK1. 3 / 3
| 3
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"Constitutive K-Ras G12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1."
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"Specifically, the constitutive activation of ERK2 by K-Ras G12D is necessary for the upregulation of MMP-1 RNA, its secreted protein, and its proteolytic activity."
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"Further molecular studies elicited that Kras G12D activated ERK2 and enhanced the invasion of pancreatic cancer cells via MMP-1 [XREF_BIBR]."
Mutated KRAS activates MAPK1. 2 / 2
| 2
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"This evidence suggests that constitutive activation of MAPK1 synergistically induced by frequent mutation of KRAS2 and the loss of function of DUSP6 plays key roles in pancreatic carcinogenesis and progression."
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"In our study, we demonstrated that up-regulation of E-cadherin by AKR1B10 knocked down or inhibition in CD18 pancreatic carcinoma cells appeared via down-regulation of mutant Kras activated ERK2, Akt and Ikk-alpha and NF-kappaB signaling, which was parallel with the effect of siRNA-knockdown K-Ras in CD18 pancreatic carcinoma cells."
KRAS-G12V activates MAPK1. 1 / 1
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bel
"ERK phosphorylation that was constitutive in mutant ras MM cells was completely abolished by the MEK inhibitor PD98059 (Figure 2C, left panels), as was the ERK phosphorylation reinduced in wild-type cells by readdition of IL-6 (Figure 2C, right panel).......In addition, re-exposure to IL-6 could reinduce AKT phosphorylation in wild-type cells in a wortmannin-sensitive fashion. Moreover, the constitutively maintained AKT phosphorylation in the mutation-containing cells was also sensitive to wortmannin. These data indicate the PI3-K/AKT cascade is a ras effector in these mutant ras–containing MM cells."
KRAS-G12V activates MAPK1. 1 / 1
| 1
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"XREF_BIBR, XREF_BIBR) The present study clearly showed that KRAS G12V as well G12A induced ERK1 and ERK2 activation and anchorage independent growth in NIH3T3 cells and the growth advantage of mutated KRAS transfected MOTN-1 cells in IL-2 depleted medium."