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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active KIT leads to the phosphorylation of JAK2. 1 / 1

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bel

"JAK2 associates with c-Kit and is phosphorylated after SCF stimulation (Brizzi et al., 1994b). JAK2 activation results in phosphorylation of STAT1?, 3, 5A and 5B"

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KIT phosphorylates JAK2. 1 / 1

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"Activated KIT subsequently phosphorylates JAK, STAT, MAP kinase, and PI3 kinases, which in turn activate signalling cascades that play vital roles in differentiation and mitogenesis of GIST neoplasms [ xref ]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...