A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

IRS1 leads to the phosphorylation of AKT1 on S473. 2 / 2
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"IRS-1 knockdown in both cell lines resulted in reduction of insulin stimulated Akt1 phosphorylation at Ser 473. In parental HepG2 cells, IRS-1 knockdown resulted in reduction (ca. 50%) in the basal level of phosphorylated mTOR (Ser 2448) irrespective of insulin treatment."
"Despite increased relative protein abundance of the insulin receptor, insulin receptor substrate (IRS1) phosphorylation was increased (P = 0.0005) at S307, an inhibitory site, and phosphorylated protein kinase B (AKT) (S473) was decreased (P = 0.03) likely serving to impair insulin signaling following 12 h of HS."
Phosphorylated IRS1 leads to the phosphorylation of AKT1. 1 / 1
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"The downregulation of insulin response under oxidant exposure involves activation of tumor necrosis factor-alpha; increased Ser/Thr phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS1) reduces the redistribution of IRS1 and phosphatidylinositol 3 kinase from the cytosolic to microsomal fraction, reduces protein kinase-B (Akt) phosphorylation, and results in decreased trafficking of GLUT4 to the plasma membrane."