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INS leads to the phosphorylation of JAK2. 10 / 13
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"In carp hepatocytes, insulin did not trigger JAK 2 and STAT 5 phosphorylation but the elevation in IGF-I and -II mRNA levels induced by insulin were blocked by inhibiting JAK 2 and STAT 5 (by AG490 and NICO, respectively)."

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"To investigate whether insulin could induce JAK2 tyrosine phosphorylation in the rat hypothalamus, as described in other tissues and cultured cells , we infused insulin i."

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"The acute treatment with epinephrine showed no difference in insulin-induced JAK2 tyrosine phosphorylation or JAK2/STAT1 and JAK2/SHP2 association in comparison with the control."

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"In carp hepatocytes, insulin did not trigger JAK 2 and STAT 5 phosphorylation but the elevation in IGF-I and -II mRNA levels induced by insulin were blocked by inhibiting JAK 2 and STAT 5 (by AG490 and NICO, respectively)."

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"That is, insulin induces JAK2 tyrosine phosphorylation, and also increases STAT3 phosphorylation and activation in the presence of leptin [37] ."

"1) insulin and IGF-1 lead to phosphorylation and activation of JAK-1 and JAK-2 in intact cells"

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"Saad et al. reported that insulin induces tyrosine phosphorylation of JAK2 ()."

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"Akt, FoxO1, JAK2, and STAT3 phosphorylation in response to ICV insulin or leptin, respectively, were evaluated as described."

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"In agreement with this hypothesis, the time-course of insulin-induced JAK2 tyrosine phosphorylation preceded that of OBR phosphorylation."

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"In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase."
INS leads to the phosphorylation of JAK2 on tyrosine. 8 / 8
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"Saad et al. reported that insulin induces tyrosine phosphorylation of JAK2 (Saad et al., 1996)."

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"Insulin induces tyrosine phosphorylation of JAK2 in insulin sensitive tissues of the intact rat."

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"Both Jak-1 and Jak-2 are tyrosine phosphorylated in response to insulin in fat and skeletal muscle cells, yet Jak-1 is phosphorylated more rapidly in comparison with Jak-2 [XREF_BIBR, XREF_BIBR]."

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"The acute treatment with epinephrine showed no difference in insulin induced JAK2 tyrosine phosphorylation or JAK2 and STAT1 and JAK2 and SHP2 association in comparison with the control."

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"Insulin induces phosphorylation and activation of JAK2 tyrosine, as well as its association with STAT1 and SHP2 in insulin sensitive tissues of intact rats, thus demonstrating a new pathway in transduction of insulin signals."

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"That is, insulin induces JAK2 tyrosine phosphorylation, and also increases STAT3 phosphorylation and activation in the presence of leptin [37]."

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"In mice treated with ASO, insulin induced Akt and Foxo1 phosphorylation and leptin induced JAK2 and STAT3 tyrosine phosphorylation were not altered, indicating that the blunted insulin and leptin effects on food intake in mice treated with ASO are independent from these pathways (XREF_FIG)."

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"To investigate whether insulin could induce JAK2 tyrosine phosphorylation in the rat hypothalamus, as described in other tissues and cultured cells [30,46], we infused insulin i.c.v. followed by immun[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"