IndraLab

Statements

INS phosphorylates SHC1. 10 / 17
1 | 1 15
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"Molecules involved in mitogenic signaling such as Grb2, SHC, and MAPK have been found to co-localize with the endosomal IR ( xref ) and inhibition of IR internalization significantly reduces insulin-induced Shc and MAPK phosphorylation ( xref )."
26217307
sparser
"However, insulin-induced tyrosine phosphorylation of the insulin receptor and SHC, and the association of SHC/growth factor receptor binding protein-2 (GRB2) decreased significantly from d 1 to wk 60 of life in both types of tissues."
11954667
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"In rat aortic VSMC, insulin induced rapid phosphorylation of the IR and Shc and caused a 5.3-fold increase in activated, phosphorylated ERK1/2 at 10 min."
10764814
sparser
"Although overexpression of SHIP2 did not affect insulin-induced tyrosine phosphorylation of the insulin receptor beta-subunit and Shc, subsequent association of Shc with Grb2 was inhibited, possibly by competition between the SH2 domains of SHIP2 and Grb2 for the Shc phosphotyrosine."
10381377
sparser
"The dissociation of insulin-induced IRS-1 and Shc tyrosine phosphorylation has been described in cell lines with mutations at two tyrosine phosphorylation sites (Y1158, Y1162F, Y1163F-YFF) on the insu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9468304
sparser
"As yet, there has been no comparison of insulin-induced IRS-1 and Shc tyrosine phosphorylation in situations of insulin resistance accompanied by a reduction in insulin receptor phosphorylation."
9468304
sparser
"Thus, interference with the IRS-1-IR interaction inhibits insulin-stimulated IRS-1 and Shc phosphorylation, PI 3-K enzymatic activity, p70s6k activation, MAPK phosphorylation and cell cycle progression."
9372969
sparser
"Insulin-dependent phosphorylation of IRS1/2 and Shc was not affected by siJAK2, but insulin-induced phosphorylation of the mitogen-activated protein kinases (MAPKs) extracellular signal-related kinase, p38, and Jun NH2-terminal kinase and their respective upstream kinases MKK1/2, MKK3/6, and MKK4/7 was significantly lowered when JAK2 was depleted, correlating with a significant drop in insulin-mediated cell proliferation."
16567515
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"Insulin and IGF-1 stimulated tyrosine phosphorylation of IRS-1 and Shc in a similar dose- and time-dependent manner."
8828504
sparser
"Consistent with a receptor level effect, in vivo insulin-dependent tyrosine phosphorylation of both IRS-1 and Shc was increased by a similar 3-fold with LAR suppression."
8557682
INS phosphorylates SHC1 on tyrosine. 1 / 1
| 1
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"In CHO-IR cells, insulin rapidly phosphorylated IRS-1 and Shc at tyrosine residues and stimulated the formation of the active GTP-bound Ras (Ras."
7508445
INS leads to the phosphorylation of SHC1 on S36. 1 / 1
| 1
reach
"In CHO cells, insulin also induces MEK dependent S36 phosphorylation of p66Shc and results in the inactivation of Ras [XREF_BIBR] in a manner similar to the insulin stimulated MEK dependent SOS phosphorylation [XREF_BIBR]."
20111892