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IL6 increases the amount of IGF1R. 2 / 2
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"In addition, IL-6 treatment induced IGF-1 secretion and IGF-1R expression in NANOG and OCT4-HCC cell lines in a dose dependent manner [XREF_BIBR], suggesting crosstalk between IL-6 and STAT3 signaling and IGF and IGF-1R signaling in HCC cancer stem cells (XREF_FIG)."
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"However, the protein expressions of thyroid-stimulating hormone receptor and insulin-like growth factor 1 receptor could not be directly increased by IL-6/sIL-6R stimulation in CD34+ OFs."
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IL6 increases the amount of IGF1R bound to IL6R. 1 / 1
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"Accordingly, under the cellular context of the elevated expression of IL- 6Ra on myeloma cells, it is assumed that IL-6Ra molecules are located close to IGF-I receptors at lipid rafts, and IL-6 stimulation triggers the complex formation of IL-6Ra not only with gp130 but also with IGF-I receptors, leading to autophosphorylation of IGF-I receptor b and subsequent acti- vation of PI-3 kinase-Akt pathways (Fig. 4) 79 ."
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