IndraLab

Statements

IL6 phosphorylates FOXO1. 3 / 3
1 | 2
bel
"Since previous reports have demonstrated that acti- vated FKHR induces p27KIP1 protein (Dijkers et al., 2000; Medema et al., 2000; Nakamura et al., 2000) and our data demonstrate that FKHR phosphorylation (inactivation) in MM.1S cells is triggered by IL-6 via PI3-K/Akt (Figure 2),"
11593406
reach
"Our results show that Akt and the three members of the mammalian FH transcription factors FKHRL1, FKHR, and AFX are phosphorylated in response to IL-6 in the myeloma cell line RPMI-8226 (Figs. 1A and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12359217
reach
"We demonstrate that both Gsk3 and FH transcription factors FKHRL1 (FOX3a), FKHR (FOXO1a), and AFX (FOXO4) are phosphorylated (inactivated) by IL-6."
12359217