IndraLab

Statements

IL1B activates AKT. 10 / 55
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"In our previous study [XREF_BIBR], IL-1beta stimulated Akt activation in DOK and OSCC cells, thus facilitating a negative feedback regulation mechanism."
26462152
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"Addition of 1 ng/ml IL-1beta activated both p42 and p44 MAPK as well as AKT."
19155066
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"These results indicate that the p38 and MAPK and PI3K and Akt signaling pathways activated by IL-1beta play a critical role in these morphological changes, leading to VM responses."
34055597
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"We found that short-term IL-1beta and TNF-alpha treatment not only activated pro inflammatory pathways involving phosphorylation of JNK, IKKalpha, and p38MAPKalpha, but also induced strong transient a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22513786
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"We demonstrated evidence that loss of Chop represses Hmgb1 and TLR4 signaling following UUO induction, leading to repressed NFkappaB transcriptional activity along with suppressed IL-1beta production, which then reduces TGF-beta1 production and Pi3K and Akt activity to attenuate the development of renal fibrosis."
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"XREF_BIBR, XREF_BIBR Of note, other than stimulating TGF-beta1 secretion, there is also evidence indicating that IL-1beta can activate PI3K and Akt signaling, 27 and thereby enhancing renal fibrosis."
26247732
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"The results clearly show that IL-1beta induced Akt activation in a time dependent manner; PDGF-bb or IGF-1 inhibited this process (XREF_FIG)."
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"In the current study, IL-1β did not induce significant VEGFR2 phosphorylation or Akt activation, and it induced only minimal GSK3β phosphorylation."
20548028
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"13 Thus, IL-1beta upregulation may be a key process in TLR2 mediated cardiac adaptive response to pressure overload, although the mechanisms in which the TLR2 and IL-1beta axis induces IGF-1 upregulation and Akt activation remain nonelucidated."
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"In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation."
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IL1B activates AKT. 1 / 1
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"In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation."
11976320