IndraLab

Statements

APEX1 activates APEX1. 10 / 29
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"The APX activity was reduced by all seed treatments and the greatest decrease in APX activity were measured with seed treatments of willow extracts ."
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"Together, our study demonstrates that increased acetylation levels of APE1 in tumor cells inhibit the limited N-terminal proteolysis of APE1 and thereby maintain the functions of APE1 to promote tumor cells ' sustained proliferation and survival."
26981776
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"Finally, deacetylation of APE1 by SIRT1 promotes the dissociation of APE1 from G4 structures, and, subsequently, 3 ' to 5 ' DNA helicases such as WRN or BLM are recruited to resolve the G4 structures."
32404420
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"The redox status of a cysteine residue in the carboxy-terminal TAD (TAD-C) has been shown to affect its interaction with CBP and p300 coactivators, and this interaction is positively regulated by redo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11248550
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"Ubiquitination of APE1 at multiple Lys (Lys 24, 25, 27) residues in the N-terminal domain was shown to modulate the stability or localization of APE1 [XREF_BIBR - XREF_BIBR]."
27655688
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"Methylation of APE1 enhanced its interaction with the mitochondrial protein, Tom20, and stimulated the mitochondrial translocation of APE1 in cells exposed to oxidative agents."
32679368
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"These data together suggest that acetylation of APE1 induces a conformational change in APE1."
27994014
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"Collectively, these findings suggest that genotoxic stress upregulates SIRT1 and acetylates APE1, and the increase in SIRT1 expression acts to deacetylate APE1, thereby allowing formation of the APE1 : XRCC1 complex in the BER pathway."
19934257
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"It is possible that the dysbiotic microbiota enhance the level of APE1 to provoke redox role or DNA repair activity similar to pathogenic bacteria induced APE1 activity XREF_BIBR."
27471558
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"Inhibition of the APEX1 gene or protein by shRNA or an APEX inhibitor , respectively , reduces the proliferation of the MM cells ."
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APEX1 bound to TXN activates APEX1. 1 / 1
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"Trx enhances the DNA binding activity of the activator protein 1 (AP1) transcription factor through an activation cascade beginning with Trx, proceeding to another regulatory protein, redox factor-1 (Ref1), and subsequently continuing to AP1 through direct cysteine mediated associations and reduction processes (Xanthoudakis and Curran, 1992; Xanthoudakis et al., 1994; Hirota et al., 1997)."
15480426
APEX1 bound to SIRT6 activates APEX1. 1 / 1
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"We show that mouse Sirt6 (mSirt6) interacts with MYH, APE1, and 9-1-1 and stimulates MYH and APE1 activities."
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