IndraLab

Statements

IGF1R phosphorylates IRS1. 10 / 64
2 | 1 27 27 6
rlimsp
"Once stimulated, the tyrosine kinase activity of IGF-1R leads to its autophosphorylation as well as the phosphorylation of a number of intracellular proteins, such as IRS-1, Shc and Gab1."
17129375
reach
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
rlimsp
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
sparser
"Following IRS1 activation, IGF1R phosphorylates IRS1 leading to its ubiquitination by FBXO40 and its degradation by the 26S proteasome, in cultured myotube and in mice [ xref , xref ]."
33466753
sparser
"Activated PP1 is sufficient to dephosphorylate at least four IRS1 Ser residues, Ser 318 , Ser 346 , Ser 612 , and Ser 789 , and promotes IRS1 YXXM phosphorylation by the IGF1R to activate the PI3K/AKT cascade."
27856640
trips
"In the absence of IGF-I stimulation, or if mutated IGF-IR fails to phosphorylate IRS-1, localization of Rad51 to the sites of damaged DNA is diminished."
14559999
reach
"In prostate cancer cells, co-inhibition of epidermal growth factor receptor and IGF-1R reduced phosphorylation of IRS-1 and its interaction with RAD51, suppressing HR and increasing radio-sensitivity [XREF_BIBR]."
26510816
signor
"Binding of IGF1 to its receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation, thus generating docking sites for insulin receptor substrate (IRS), which is also phosphorylated by the IGF1 receptor."
21798082
sparser
"One pathway involves IRS-1, which becomes tyrosine phosphorylated by IGF-IR and binds the Grb2/Sos complex through the SH2 domain of Grb2."
12837295
sparser
"Both IGF-I and IGF-II bind the tyrosine kinase receptor IGF1R, which in turn phosphorylates the insulin receptor substrates IRS-1 and IRS-2."
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IGF1R phosphorylates IRS1 on tyrosine. 10 / 12
| 10 2
reach
"IGF-I rapidly stimulated beta-chain IGF-I receptor autophosphorylation, which peaked at a physiological and mitogenic concentration (1.4 nM) and also stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)."
8756554
reach
"Downregulation of beta 1 blocks IGF stimulated cell proliferation and transformation of prostate cancer cells, but the effect of beta 1 downregulation on activation of IGF-IR and tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) has never been described."
20333644
rlimsp
"Neither the autophosphorylation of the IGF-IR nor the tyrosyl phosphorylation of IRS-1 was affected by the expression of the MyCF plasmid."
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reach
"Upon binding of IGF-I or IGF-II, IGF-1R, a tyrosine kinase, phosphorylates tyrosine residues on two major substrates, IRS-1 and Shc, which subsequently signal through the Ras and Raf and PI 3-kinase/AKT pathways (7)."
15500006
reach
"IGF-I-stimulated autophosphorylation of the IGF-IR and tyrosine phosphorylation of IRS-1 and SHC, known substrates in the IGF-IR signal transduction pathway, were studied."
9202243
reach
"When cells are only stimulated by IGF-I, the IGF-IR induces the tyrosine phosphorylation of IRS-1 which recruits docking proteins such as PI 3-kinase and initiates specific IGF downstream signaling pa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
reach
"On ligand stimulation, IGF-IR, a receptor tyrosine kinase, phosphorylates tyrosine residues on two major substrates, IRS-1 and Shc, which subsequently signal through the Ras and mitogen activated protein kinase and phosphatidylinositol 3-kinase/AKT pathways."
16093437
reach
"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [XREF_BIBR, XREF_BIBR], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF induced IRS-1 tyrosine phosphorylation in EGFR transfected CHO cells [XREF_BIBR]."
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reach
"Insulin like growth factor 1 receptor is an RTK, and phosphorylates multiple tyrosine residues of IRS1 to activate PI3K and its downstream signal pathway including Akt, mTOR, and S6K1."
25483727
reach
"IGF-1R is a tyrosine kinase receptor that is activated by IGFs, the activated IGF-1R not only phosphorylates IRS-1 and SHC to activate the MAPK cascade, which stimulates cell growth and proliferation [XREF_BIBR], but also protects from apoptosis as a result of activation of PI3K-Akt through phosphorylation and subsequent inactivation of BAD [XREF_BIBR]."
24810113
IGF1R phosphorylates IRS1 on Y612. 6 / 6
1 | 3 1 1
reach
"IGF-IR phosphorylates IRS-1 on Y612, a PI3-K recruitment site, while EGFR preferentially phosphorylates IRS-1 on Y896, a Grb2 binding site."
20670944
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
rlimsp
"IRS-1 is generally considered to be a unique substrate of IGF-IR, which phosphorylates IRS-1 at Y612."
25886138
reach
"Inhibition of IGF-IR by NVP-AEW541 decreased IGF-I-induced phosphorylation of Akt and IRS-1 (Y612)."
25886138
reach
"IRS-1 is generally considered to be a unique substrate of IGF-IR, which phosphorylates IRS-1 at Y612."
25886138
sparser
"IGF-IR phosphorylates IRS-1 on Y612, a PI3-K recruitment site, while EGFR preferentially phosphorylates IRS-1 on Y896, a Grb2 binding site."
20670944
IGF1R phosphorylates IRS1 on Y896. 4 / 4
1 1 1 | 1
hprd
No evidence text available
8530377
rlimsp
"The IRS-1 phosphorylation pattern clearly indicated that blocking IGF-IR signaling strongly induced phosphorylation of IRS-1 at Y896."
25886138
biopax:phosphositeplus
No evidence text available
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
Kinase-active IGF1R phosphorylates IRS1 on tyrosine. 4 / 4
4 |
bel
"At least nine intracellular substrates of the insulin/IGF-I receptor kinases have been identified (Fig. 2). Four of these belong to the family of insulin-receptor substrate (IRS) proteins9. Other substrates include Gab-1, p60dok, Cbl, APS and isoforms of Shc10."
11742412
bel
"from http://www.ub.rug.nl/eldoc/dis/medicine/n.wilczak/c1.pdf The intrinsic tyrosine kinase activity of the IGF-I receptor is enhanced and phosphorylates multiple substrates, including IRS1 and IRS2 on tyrosine residues"
bel
"upon binding of IGF1, the IGFR, which is a receptor tyrosine kinase, becomes phosphorylated and recruits the substrate IRS1, leading to the activation of the lipid kinase PI3K"
15292521
bel
"Accordingly, under the cellular context of the elevated expression of IL- 6Ra on myeloma cells, it is assumed that IL-6Ra molecules are located close to IGF-I receptors at lipid rafts, and IL-6 stimulation triggers the complex formation of IL-6Ra not only with gp130 but also with IGF-I receptors, leading to autophosphorylation of IGF-I receptor b and subsequent acti- vation of PI-3 kinase-Akt pathways (Fig. 4) 79 ."
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IGF1R phosphorylates IRS1 on Y632. 2 / 2
1 1 |
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
biopax:phosphositeplus
No evidence text available
IGF1R phosphorylates IRS1 on Y941. 2 / 2
1 1 |
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
biopax:phosphositeplus
No evidence text available
IGF1R phosphorylates IRS1 on Y1179. 2 / 2
1 1 |
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
biopax:phosphositeplus
No evidence text available
Phosphorylated IGF1R leads to the phosphorylation of IRS1. 2 / 2
| 2
reach
"Binding of IGF1 to its receptor leads to phosphorylation of IGF1R, which further leads to phosphorylation and recruitment of the insulin receptor substrate-1 (IRS-1) and PI3K, consequently resulting in activation of downstream signaling components like AKT and MAPK pathways."
32659913
reach
"XREF_BIBR, XREF_BIBR The ligand mediated phosphorylation of IGF1R leads to the recruitment and phosphorylation of insulin receptor substrate IRS-1 and IRS-2, which in turn results in the activation of PI3K and AKT signaling for cell proliferation and survival."
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IGF1R phosphorylates IRS1 on Y989. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
IGF1R phosphorylates IRS1 on S616. 1 / 1
| 1
rlimsp
"Activated PP1 is sufficient to dephosphorylate at least four IRS1 Ser residues, Ser318, Ser346, Ser612, and Ser789, and promotes IRS1 YXXM phosphorylation by the IGF1R to activate the PI3K/AKT cascade."
27856640
IGF1R phosphorylates IRS1 on Y1229. 1 / 1
1 |
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
IGF1R phosphorylates IRS1 on Y662. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
IGF1R phosphorylates IRS1 on Y732. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
IGF1R phosphorylates IRS1 on Y465. 1 / 1
1 |
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
Tyrosine-phosphorylated IGF1R leads to the phosphorylation of IRS1 on tyrosine. 1 / 1
| 1
reach
"Tyrosine phosphorylation of IGF1R induces the binding of IRS1 to IGF1R, and phosphorylation of tyrosine residues in IRS1."
29290648
IGF1R leads to the phosphorylation of IRS1 on serine. 1 / 1
| 1
reach
"We present new IGF-IR and IRS-targeted agents (NT compounds) that promote inhibitory Ser phosphorylation and degradation of IRS1 and IRS2."
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