IndraLab

Statements

IGF1R leads to the phosphorylation of SRC. 4 / 4
| 1 1 2
rlimsp
"These findings revealed the ability of IGF-1R to phosphorylate Src."
26041671
sparser
"Activated IGFR in turn phosphorylates the insulin receptor substrate 1–4 and src- and collagen-homology adaptor proteins, which can trigger multiple downstream signal transduction pathways ."
12901945
reach
"In addition, C-ANP 4-23 treatment also attenuated the enhanced expression of AT1 receptor, Gqalpha, PLCbeta1, Nox4, and p47 phox proteins, the enhanced activation of EGFR, PDGFR, IGF-1R, enhanced phosphorylation of ERK1/2/AKT and c-Src in VSMC from SHR."
29417757
rlimsp
"An in vitro kinase assay showed that IGF-1R immunoprecipitated from A549 cells phosphorylated Src (Fig. 2k; Additional file 6: Figure S5F)."
26041671
IGF1R phosphorylates SRC on Y419. 1 / 1
| 1
sparser
"Extracellular signals such as PDGFR, HER family members (HER1; HER2 and HER3), and IGF1R can phosphorylate SRC on Tyr416, which is followed by activation of MAPK, PI3K, and STAT3-signaling pathways and results in cell differentiation and proliferation xref , xref ."
32683421
Kinase-active IGF1R leads to the phosphorylation of SRC. 1 / 1
1 |
bel
"While the cell lines overexpressing the IGF1-R had higher levels of Src activation, the use of a Src inhibitor reduced the IGF1-R protein expression, slowed down the proliferation of IGF1-R(+) cells, and reduced their colony formation in soft agar."
12820418