IndraLab

Statements

IGF1 increases the amount of EGFR. 10 / 14
1 | 9
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"Based on the molecular level, IGF-1 enhanced the expression of epidermal growth factor receptor (EGFR) and matrix metalloprotein 9 (MMP9) in CM cells, whereas knockdown of MEF2D was able to reduce the expression of EGFR and MMP9 compared with vector control."
26563368
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"Neither EGF nor IGF-I alone stimulated significant keratinocyte spread or proliferation, although IGF-I and insulin acted synergistically with EGF because IGF-I or high doses of insulin upregulated the expression of the EGF receptor and keratinocyte responsiveness to EGF."
25288883
bel
"Incubation of DU-145 cells with IGF-1 (100ng/ml) induced the activity of p42/ERK2. Preincubation of these cells with MAb-EGFR-528 (for one hour) resulted in inhibition of the IGF-1 induced p42/ERK2 activity. This suggests that IGF-1 activate the ERK pathway via the involvement of the EGF receptor. p42/ERK2 activity induced by IGF-1 was also observed in LNCaP cells."
9892211
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"In summary, the present study demonstrated that IGF-I can stimulate egfr expression in both follicle cell culture and intact follicles."
26599586
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"Of particular interest, our results showed that IGF-I can not only stimulate egfr expression, but also promote the phosphorylation of Egfr."
26599586
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"Second, IGF-I also increased the protein level of Egfr."
26599586
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"As demonstrated in Fig. 1 C and D, IGF-I significantly enhanced the expression of egfr in the FG follicles time- and dose-dependently."
26599586
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"We therefore tested whether IGF-I stimulates egfr expression."
26599586
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"We also examined whether IGF-I can promote egfr expression in the intact full-grown follicles (FG follicles)."
26599586
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"First, IGF-I up-regulated egfr mRNA level in a time- and dose dependent manner in both primary cell culture and intact FG follicles."
26599586
Modified IGF1 increases the amount of EGFR. 1 / 1
| 1
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"Median levels of total or free IGF-1 and IGF-2 were not modulated during treatment, however, median levels of soluble EGFR decreased in patients on the CET + CIX arm (p < 0.00001)."
29909907