IndraLab

Statements

HRAS increases the amount of CDKN1A. 4 / 5
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"In addition, expression levels of p53 and p21 WAF1 and CIP1 were increased by H-RAS V12 transfection."
32264658
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"Western blot results (XREF_SUPPLEMENTARY) show that knockdown of either HRAS or KRAS in HemSCs also decreased the protein levels of cyclin D1 and phosphorylation of RB1 but increased the protein levels of p21 and p53."
33400686
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"In addition, expression levels of p53 and p21 WAF1 and CIP1 were increased by H-RAS V12 transfection."
32264658
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"As shown in XREF_FIG, overexpression of constitutively activated HRAS or KRAS in HemSCs treated with siNGBR restored the protein levels of cyclin D1 and phosphorylation of RB1, p53, and p21 to the levels shown in control HemSCs transfected with siControl and empty vector."
33400686
HRAS-G12V increases the amount of CDKN1A. 2 / 2
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bel
"We found that Ras activation resulted in elevated expression of p53 (2-fold, P0.05) and p21 (17- fold, P0.01) as well as p16 (5-fold, P0.01; Figure 1B and Data Supplement Figure II), which suggests that Ras-induced growth arrest is different from quiescence, because neither p53 nor p16 accumulates during quiescence."
14557365
bel
"We found that Ras activation resulted in elevated expression of p53 (2-fold, P0.05) and p21 (17- fold, P0.01) as well as p16 (5-fold, P0.01; Figure 1B and Data Supplement Figure II), which suggests that Ras-induced growth arrest is different from quiescence, because neither p53 nor p16 accumulates during quiescence."
14557365
Modified HRAS increases the amount of CDKN1A. 1 / 1
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"Inhibition of FOXO1 activity in HRAS expressing wild-type cells reduced the percentage of beta-gal-positive cells (XREF_FIG and XREF_SUPPLEMENTARY) and the expression of p21 and p27 (XREF_FIG)."
24213576
GTP-bound active HRAS increases the amount of CDKN1A. 1 / 1
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bel
"H-RasG12V expression down-regulated p27Kip1 expression, and that RASSF1A co-transfected with H-RasG12V recovered p27Kip1 expression that had been down-regulated by H-RasG12V expression. Similarly, p21WAF1/CIP1 was induced by H-RasG12V expression and RASSF1A co-transfected with H-RasG12V inhibited p21WAF1/CIP1 induction."
17088994