IndraLab

"However, unlike Raf-1, the phosphorylation of B-Raf at Ser(445) was constitutive and was only moderately increased by expression of constitutively active H-Ras or constitutively active PAK1. These data demonstrate that B-Raf activity is autoregulated, that constitutive phosphorylation of Ser(445) primes B-Raf for activation, and that a key feature of phosphorylation within the activation loop or of oncogenic mutations within this region is to block autoinhibition."

15710605

Modified HRAS leads to the phosphorylation of BRAF at position 445. 1 / 1

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"However, unlike Raf-1, the phosphorylation of B-Raf at Ser (445) was constitutive and was only moderately increased by expression of constitutively active H-Ras or constitutively active PAK1."

15710605

HRAS phosphorylates BRAF. 1 / 1

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sparser

"One major candidate, the RET oncogene activates p21ras, which also phosphorylates wild-type BRAF, as a potent mitogen-activated protein phosphorylase."

30666518

Modified HRAS leads to the phosphorylation of BRAF on serine. 1 / 1

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reach

"However, unlike Raf-1, the phosphorylation of B-Raf at Ser (445) was constitutive and was only moderately increased by expression of constitutively active H-Ras or constitutively active PAK1."

15710605

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HRAS phosphorylates BRAF on T373. 9 / 9

HRAS phosphorylates BRAF phosphorylated on S446 on S602. 5 / 5

HRAS phosphorylates BRAF phosphorylated on S446 on T599. 5 / 5

HRAS phosphorylates BRAF on S579. 5 / 5

GTP-bound active HRAS leads to the phosphorylation of BRAF on S446. 1 / 1

Modified HRAS leads to the phosphorylation of BRAF at position 445. 1 / 1

HRAS phosphorylates BRAF. 1 / 1

Modified HRAS leads to the phosphorylation of BRAF on serine. 1 / 1

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