IndraLab

Statements

HIF1A increases the amount of ANGPT2. 4 / 5
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"Hypoxic cirrhotic nodules expressing HBx promotes survival and growth through transcriptional activation and stabilization of HIF1alpha, which activates transcription of Ang-2 and vascular endothelial growth factor to promote angiogenesis and metastasis [XREF_BIBR]."
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"Expression of Ang-2 is upregulated by hypoxia, HIF-1alpha, VEGF-A, angiotensin-II, leptin and glucose in bovine microvascular endothelial cells [XREF_BIBR]."
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"Though HIF-1alpha protein accumulation is diminished in aged mice cerebral cortex stabilized VEGF and upregulated Ang-2 expressions through HIF-1 independent pathways maintain the balance in vascular proangiogenic proteins to enhance brain vascular angiogenesis in prolonged hypoxia."
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"Our findings suggest that the hypoxia elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1alpha pathways, while celecoxib could counteract the hypoxia induced Ang-2 expression."
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Transcriptionally active HIF1A increases the amount of ANGPT2. 2 / 2
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"In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4)"
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"In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4)"
12958144
Modified HIF1A increases the amount of ANGPT2. 1 / 1
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"Our study confirmed that HIF-1alpha and HIF-2alpha overexpression significantly enhanced the protein and mRNA expression of VEGF, Notch1, DLL4, and Ang2, which are key factors during angiogenesis."
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