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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

GRB2 activates RAF1. 1 / 3

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"The binding of GRB2 to phosphorylated PDGF-R results in the recruitment of Sos to the plasma membrane, and GRB2 and Sos stimulates the Ser/Thr kinase Raf1 which stimulates MAPK ERK1/2 (Dance et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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GRB2 bound to TNFRSF1A activates RAF1. 1 / 1

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"The TNFR-I/Grb2 interaction is essential for the TNF-alpha-dependent activation of c-Raf-1 kinase"

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...