A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

GRB2 activates MAPK1. 5 / 8
| 1 4
reach
"We hypothesised that inhibition of Grb2 would suppress ERK1 and ERK2 activation and inhibit leukaemia progression."
sparser
"Src mediated phosphorylation of FAK at Y925 creates a docking site for GRB2 which activates the small GTP protein RAS and the downstream ERK2 (MAPK) that is known to play an important role in directed cell motility and invasion."
reach
"To investigate the mechanisms by which FAK, c-Src, and Grb2 function in FN stimulated signaling events to ERK2, we expressed wild type and mutant forms of FAK in human 293 epithelial cells by transient transfection."
reach
"ERK2 phosphorylation has been shown to enhance EMT [XREF_BIBR], and we found that overexpression of GRB2 enhanced ERK phosphorylation and this was further enhanced by TGF-beta1 treatment, suggesting that GRB2 may enhance EMT by stabilising phospho-ERK2."
reach
"Expression of the Grb2 binding site Phe 925 mutant of FAK enhanced activation of ERK2, whereas a kinase-inactive Arg 454 mutant FAK did not."
GRB2 bound to SOS1 activates MAPK1. 1 / 1
1 |
bel
"the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway."
GRB2 bound to KIT activates MAPK1. 1 / 1
1 |
bel
"The adapter protein Grb2 can directly associate with phosphorylated Y703 and Y936 in c-Kit"
GRB2 bound to SHC activates MAPK1. 1 / 1
| 1
reach
"The inhibition of Shc and Grb2 interaction by actinomycin D in B104-1-1 cells also reduced tyrosine phosphorylation of MAP kinase (Erk1 and Erk2), one of the major components in the Ras-MAP kinase signaling pathway."
GRB2 activates MAPK1. 1 / 1
1 |
bel
"Pyk2-induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades. Expression of a Grb2 mutant with a deletion of the amino-terminal Src homology 3 domain or the carboxyl-terminal tail of Sos strongly reduced Pyk2-induced ERK activation, with no apparent effect on JNK activity."