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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Catalytically active GFRA1 activates MET. 1 / 1
1 |
bel
"Both branching and chemotaxis are promoted by GDNF in cells co-expressing RET and GFR1, which mimics the effects of hepatocyte growth factor (HGF) signalling through the Met receptor tyrosine kinase in wild-type MDCK cells. GDNF induces Met phosphorylation in several RET-deficient but GFR1-positive cells, as well as in cell lines coexpressing GFR1 and RET. Met might therefore contribute to RET-independent GDNF signalling."