A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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MTOR increases the amount of MDM2. 8 / 8
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"Second, there are two major regulatory mechanisms to modulate MDM2 protein levels : p53 dependent transcriptional regulation and mTOR dependent translational control."
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"To find out how inhibition of PI3K and mTOR inhibited MDM2 expression, we performed Western blot analysis with lysates prepared from cells treated with BEZ235."
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"In addition, MDM2 expression may be enhanced by mTOR through the translational machinery [XREF_BIBR]."
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"In addition, even in the absence of increased transcription, as in the case of Tp53 -/- background, mTOR activation still increased Mdm2 protein levels (XREF_FIG), suggesting that mTOR increases Mdm2 protein levels by p53 dependent and p53 independent mechanisms."
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"Furthermore, the decreased activity of mTOR in these cells caused a significant reduction in the expression of MDM2 protein (XREF_FIG C) that in turn induced a rising of p53 levels, not detected in control cells (XREF_FIG A and B)."
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"Moreover, in vivo inhibition of mTOR downregulates Mdm2 protein levels and induces p53 dependent apoptosis."
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"mTOR activation increased expression of Mdm2, which is hereby identified as the necessary and sufficient ubiquitin E3 ligase for Drosha."
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"The increased activity of mTOR kinase enhances the expression of E3 ubiquitin ligase MDM2 that in turn promotes p53 ubiquitination, leading to its degradation by proteasome machinery in a network involving p70S6K."
Kinase-active MTOR increases the amount of MDM2. 1 / 1
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bel
"mTOR inhibits p53 by promoting the translation of Mdm2, a negative regulator of p53."