IndraLab

Statements

MTOR inhibits IRS1. 10 / 43
7 | 1 27 6
reach
"In addition to diabetes, mTOR/S6K1-mediated feedback inhibition of IRS1 and by extension the oncogenic PI3K/Akt pathway poses drawbacks for cancer therapy and limits the cytotoxic effects of rapamycin-based therapeutic approaches [75]."
32054043
reach
"Rapamycin has been reported to have alternate effects on Akt phosphorylation; prolonged rapamycin exposure has been shown to inhibit assembly of mTORC2, thereby inhibiting Akt, and mTOR inhibition has also been described to induce insulin receptor substrate-1 (IRS-1), leading to Akt activation."
18701474
signor
"Mtor induced the serine phosphorylation of irs-1 (ser-636/639), and such phosphorylation was inhibited by rapamycin. These results suggest that tnf impairs insulin signaling through irs-1 by activation of a pi 3-kinase/akt/mtor pathway, which is antagonized by pten"
11287630
reach
"In early studies mTOR inhibition led to p70 ribosomal protein S6 kinase (S6K) suppression, IRS1 upregulation, and PI3K-AKT activation 181."
25533673
reach
"On the other hand, chronic beta-cell hyperfunction, a consequence of excessive leucine exposure, results in accelerated beta-cell apoptosis and eventual secretory deficiency through a negative feedback loop involving the mTOR dependent inhibition of IRS-1 [XREF_BIBR]."
24685128
reach
"Calorie restriction and/or GH resistance decreases mTOR signaling and phosphoSer inhibition of IRS-1 in skeletal muscle."
19234595
reach
"Current mTOR inhibition causes the upregulation of the Ras and Raf pathway and inhibition of the negative feedback loop of IRS1 while inhibition of IGF signaling has been shown to inhibit growth and induce death of cancer cells with upregulated PI3K."
24244833
sparser
"One well characterized negative feedback loop involves the tuberous sclerosis complex (TSC), the Rheb RAS superfamily member, the kinase mTOR, and the mTOR target p70 ribosomal S6 kinase (p70S6K) that inhibits insulin receptor substrate 1 (IRS1) and insulin-like growth factor receptor (IGFR) signaling ( xref ; xref ; xref )."
21666717
reach
"This restoration of IRS-1 mRNA abundance by sustained rapamycin treatment is reversed by actinomycin D (XREF_FIG), indicating that mTOR and S6K1 signaling likely reduces IRS-1 mRNA abundance primarily at the level of gene transcription."
15249583
reach
"Specifically, mTOR acts through S6 kinase to inhibit IRS-1 (insulin receptor substrate) (Fig. 4C), leading to receptor signal resistance, including insulin resistance that contributes to type 2 diabetes (Blagosklonny, 2006a)."
34990845
Kinase-active MTOR inhibits IRS1. 1 / 1
1 |
bel
"Here, we demonstrate that nutrients suppress phosphatidylinositol 3 (PI3)-kinase/Akt signaling via Raptor-dependent mTOR (mammalian target of rapamycin)-mediated phosphorylation of insulin receptor substrate 1 (IRS-1). Raptor directly binds to and serves as a scaffold for mTOR-mediated phosphorylation of IRS-1 on Ser636/639"
16354680