A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

MTOR phosphorylates AKT1. 10 / 20
1 | 1 18
reach
"Although Rictor T1135 phosphorylation leads to recruitment of 14-3-3 (XREF_SUPPLEMENTARY), it does not disrupt the mTORC2 complex nor does it significantly affect the ability of Rictor and mTOR to phosphorylate Akt1 in vitro (XREF_FIG)."
reach
"The alterations in the Ane-AA group were accompanied by hyperphosphorylation of protein kinase B and the mammalian target of rapamycin (mTOR)."
reach
"However, the PI3K specific inhibitor (LY294002) inhibited CSF2 induced phosphorylation of ERK1/2 and MTOR as well as CSF2 induced phosphorylation of AKT1."
reach
"NAC also blunted the increase in phosphorylation of protein kinase B, mammalian target of rapamycin, p70 ribosomal S6 kinase, ribosomal protein S6, and mitogen activated protein kinase p38 at 2 and 8 d after exercise."
reach
"Thus, when AKT1 is correctly oriented at the cell membrane through its capacity to bind to PIP-3, AKT1 is phosphorylated by its activating kinases, PDPK-1 and mTOR complex 2 (mTORC2)."
reach
"One potential mechanism through which the mutations in mTOR (XREF_FIG) might increase S6K1 and Akt1 phosphorylation is by altering mTORC1 or mTORC2 assembly."
reach
"LA or Epo reduced the phosphorylation of the protein kinase B (Akt), a downstream target of phosphatidylinositol-3-kinases (PI3K), and mammalian target of rapamycin (mTOR) in ARPE-19 cells; by contrast, the induced changes of autophagy substrate, p62, showed biphasic pattern."
reach
"Subsequent analyses showed that Sb treatment decreased phosphorylation of protein kinase B (Akt) as well as the mammalian target of rapamycin (mTOR), while an Akt activator protected PC12 cells from autophagy."
reach
"mTOR was immunoprecipitated from PC3 from control cells or cells treated with siRNA to IKKalpha, and the ability of mTOR to phosphorylate recombinant Akt1 was analyzed."
sparser
"The mTOR-rictor complex (mTORC2) phosphorylates AKT1 within the carboxy terminus at S473 and PDK1 phosphorylates AKT1 within its activation loop at T308 [ xref , xref ]."
MTOR phosphorylates AKT1 on S473. 7 / 8
1 3 | 2 1
signor
"Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.Recent findings have revealed novel important roles for mTORC2 in the phosphorylation of AGC kinase family members. mTORC2 phosphorylates and activates Akt, SGK, and PKC, which regulate cell survival, cell cycle progression and anabolism"
biopax:phosphositeplus
No evidence text available
signor
"Protein kinase B (PKB, Akt) is a Ser/Thr kinase involved in the regulation of cell survival, proliferation, and metabolism and is activated by dual phosphorylation on Thr(308) in the activation loop and Ser(473) in the hydrophobic motif. It plays a contributory role to platelet function, although little is known about its regulation. In this study, we investigated the role of the mammalian target of rapamycin complex (mTORC)-2 in Akt regulation using the recently identified small molecule ATP competitive mTOR inhibitors PP242 and Torin1."
signor
"The rictor-mtor complex directly phosphorylated akt/pkb on ser473 in vitro and facilitated thr308 phosphorylation by pdk1"
sparser
"Furthermore, purified PDK-1 and immuno-precipitated mTOR readily phosphorylated purified Akt1 at T308 and S473 in vitro , respectively, regardless of whether or not TCN-P was present in the reaction mixture ( xref )."
reach
"Akt-1 is also phosphorylated at S473 by the mammalian target of Rapamycin (mTOR) complex referred to as (Rapamycin-insensitive companion of mTOR and mLST8 complex) mTORC2 [XREF_BIBR - XREF_BIBR]."
sparser
"Of note, the S473D mutant of Akt1 and Akt1 phosphorylated in Ser 473 by the rictor-mTOR complex are better targets of PDK1 than nonphosphorylated Akt1 xref ."
MTOR phosphorylates AKT1 at position 473. 2 / 2
2 |
biopax:inoh
No evidence text available
biopax:inoh
No evidence text available
MTOR phosphorylates AKT1 at position 308. 2 / 2
2 |
biopax:inoh
No evidence text available
biopax:inoh
No evidence text available
MTOR phosphorylates AKT1 on T450. 1 / 2
1 |
biopax:phosphositeplus
No evidence text available
MTOR phosphorylates AKT1 on threonine. 1 / 1
| 1
reach
"This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser (473), mTOR on Ser (2448), ribosomal protein S6 kinase on Thr (389), and eukaryotic initiation factor eIF4E binding protein on Thr (37)."
MTOR phosphorylates AKT1 phosphorylated on amino acid 308 at position 473. 1 / 1
1 |
biopax:inoh
No evidence text available
Kinase-active MTOR leads to the phosphorylation of AKT1 on S473. 1 / 1
1 |
bel
"Furthermore, we show that inhibition of mTOR by rapamycin induces the activation of Akt as shown by increased Akt phosphorylation at Ser(473) and the inhibition of 6-TG-induced apoptosis and cell death. Activated Akt is a well-known inhibitor of autophagy. "
MTOR phosphorylates AKT1 on T308. 1 / 1
| 1
sparser
"Furthermore, purified PDK-1 and immuno-precipitated mTOR readily phosphorylated purified Akt1 at T308 and S473 in vitro , respectively, regardless of whether or not TCN-P was present in the reaction mixture ( xref )."