IndraLab

Statements

MTOR activates SRC. 2 / 2
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"Phosphorylation of extracellular signal regulated kinase (ERK) (pERK), p38 mitogen activated protein kinase (MAPK), pSRC, phosphorylation of signal transducer and activator of transcription factor 1 (pSTAT1), pSTAT3, and pSTAT5 was very low to moderate in murine and human RMS cells and was not decreased by GSK212 treatment (XREF_SUPPLEMENTARY), suggesting that PI3K and mTOR signaling does not activate RAS and MAPK, SRC, or Janus activated kinase signaling in these cells."
29487419
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"The latter should be accomplished indirectly through mTOR mediated Src kinase activation since mTOR is a serine/threonine and not a tyrosine protein kinase."
| PMC
Kinase-active MTOR activates SRC. 1 / 1
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bel
"A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with imunosuppressant properties. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase"
15251441
Phosphorylated MTOR activates SRC. 1 / 1
| 1
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"In poor prognosis patients with RMS (that is, those with advanced or metastatic disease), IRS-1 activation appears refractory to normal negative feedback mediated by increased phosphorylated mTOR and S6 Kinase 88, and inhibiting IGF1R activity can promote compensatory regulatory activity of the SRC family kinase, YES 89."
30617281